Meta AnalysisID 682
外用过氧化苯甲酰治疗痤疮 [Cochrane方案]
CRD42015019326
To assess the effects of benzoyl peroxide for acne.
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Record Fields
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- Meta Analysis Id
- 682
- Evidence Id
- 9240
- Core Evidence Id
- 9240
- Source Meta Analysis Id
- 661
- Herb2 Meta Analysis Id
- HBMA000661
- Crd Id
- CRD42015019326
- Title
- Topical benzoyl peroxide for acne [Cochrane Protocol]
- Review Question
- To assess the effects of benzoyl peroxide for acne.
- Study Type Included
- We will consider randomised controlled trials (RCTs) with a parallel or cross-over design eligible for our review. We will only include the first-phase data from cross-over trials, because of the possibility of the effect of the acne interventions carrying over to subsequent periods.
- Condition Being Studied
- The Cochrane Skin Group
- Participant
- We will consider participants with a clinical diagnosis by a healthcare practitioner of acne vulgaris on the face or trunk, regardless of age, gender, severity, setting and previous treatment. We will exclude studies where individuals were diagnosed with rosacea, chloracne, acne inversa, infantile acne, occupational acne, drug-induced acne and acne associated with polycystic ovary syndrome.
- Animal
- Human Disease Modelled
- Intervention
- We will include any treatment regimen of benzoyl peroxide (including wash-off and leave-on), dose, duration and vehicle (including gel, cream, lotion, etc.) used alone or as any fixed-combination product containing benzoyl peroxide, compared with placebo, no treatment or other active topical treatments (such as retinoids, antibiotics, azelaic acid, salicylic acid, etc.). We will consider comparisons between different formulations and concentrations of benzoyl peroxide, if available. We will allow other co-interventions if they were offered equivalently to both groups of the trial.
- Comparator Control
- Placebo, no treatment or other active topical treatments (such as retinoids, antibiotics, azelaic acid, salicylic acid, etc.).
- Main Outcome
- <ol> Participant global self assessment of acne improvement. Withdrawal due to adverse effects. </ol>
- Outcome Measure
- Additional Outcome
- <ol> Change in lesion counts (total, inflamed and non-inflamed, separately). We will define a clinically significant total lesion count as more than 10 lesions. According to the number of the lesions, acne severity is graded as follows: mild acne (fewer than 20 comedones, fewer than 15 inflammatory lesions or total lesion count fewer than 30); moderate acne (20 to 100 comedones, 15 to 50 inflammatory lesions or total lesion count 30 to 125); severe acne(more than five cysts, total comedone count more than 100, total inflammatory count more than 50 or total lesion count more than 125) (Lehmann 2002). The percentage of participants rated 'clear' or 'almost clear' on the Investigator's Global Assessment (IGA) scale of acne severity. Change in quality of life (assessed with a validated instrument such as Skindex-16, Skindex-29 or Cardiff Acne Disability Index). Reduction in P. acnes strains (total and resistant). Total number of adverse events. </ol>
- Study Method
- Keyword
- Acne Vulgaris; Benzoyl Peroxide; Dermatitis; Humans; Sebaceous Gland Diseases
- Contact
- Zhirong Yang [email protected]
- Organisational Affiliation
- The Cochrane Collaboration http://www.cochrane.org/
- Funding Source
- Peking University Health Science Center, The National Institute for Health Research (NIHR), Cochrane Skin Group, Shantou-Oxford Clinical Research Unit
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- Registration Date
- 2015-04-08
- Anticipated Start Date
- 2014-06-15
- Anticipated Completion Date
- 2016-06-15
- Title Cn
- 外用过氧化苯甲酰治疗痤疮 [Cochrane方案]
- Title En
- Topical benzoyl peroxide for acne [Cochrane Protocol]
- Bilingual Status
- complete