Meta AnalysisID 672
黄体期雌二醇预处理在正常反应者中应用于促性腺激素释放激素拮抗剂方案前的疗效：一项系统评价与Meta分析
CRD42020204087
Does luteal estrodiol pretreatment prior to GnRH antagonist protocol improve efficacy of controlled ovarian stimulation?
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 672
- Evidence Id
- 9230
- Core Evidence Id
- 9230
- Source Meta Analysis Id
- 651
- Herb2 Meta Analysis Id
- HBMA000651
- Crd Id
- CRD42020204087
- Title
- The efficacy of luteal estradiol pretreatment prior to the GnRH antagonist protocol in normal responders, a systemic review and meta-analysis.
- Review Question
- Does luteal estrodiol pretreatment prior to GnRH antagonist protocol improve efficacy of controlled ovarian stimulation?
- Study Type Included
- randomized controlled trials, retrospective studies, clinical trials
- Condition Being Studied
- GnRH antagonist protocol had gaining popularity recently, however, its numbers of oocyte retrieved was not as good as GnRH agonist protocol in some of the studies. Our study aimed to answer the question of luteal estradiol pretreatment prior to GnRH antagonist protocol could improve the numbers of oocyte retrieved.
- Participant
- Participants who received controlled ovarian stimulation by GnRH antagonist protocol and luteal estradiol pretreatment were regarded as intervention group, while participants who did not receive luteal estradiol were control.
- Animal
- Human Disease Modelled
- Intervention
- To give estradiol 10mg/d for ten days from mid luteal phase until the next cycle day 1 for controlled ovarian stimulation by GnRH-antagonist protocol.
- Comparator Control
- Controlled ovarian stimulation by GnRH-antagonist/GnRH-agonist protocol without luteal estradiol pretreatment
- Main Outcome
- The numbers of oocyte retrieved, days of stimulation, total doses of gonadotropins of LE versus control was treated as the primary outcome. Measures of effect The standardized difference in means (SDMs) of numbers of oocyte retrieved, days of stimulation, total doses of gonadotropins of LE versus control was treated as the primary outcome
- Outcome Measure
- Additional Outcome
- The clinical pregnancy and live birth rate of LE versus control comprised the secondary outcome. Measures of effect The odds ratios (ORs) of clinical pregnancy and live birth rate of LE versus control comprised the secondary outcome.
- Study Method
- Intervention, Meta-analysis, Systematic review
- Keyword
- Estradiol; Gonadotropin-Releasing Hormone; Humans; Luteal Phase; Meta-Analysis as Topic; Ovulation Induction
- Contact
- Tzuyu Hung [email protected]
- Organisational Affiliation
- Mackay memorial hospital
- Funding Source
- No funding sources. Grant number(s) <span style=font-size: 14px>State the funder, grant or award number and the date of award</span> nil
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Taiwan
- Review Stage
- Review Ongoing
- First Submission Date
- 2020-08-13
- Registration Date
- 2020-09-13
- Anticipated Start Date
- 2020-08-15
- Anticipated Completion Date
- 2020-09-30
- Title Cn
- 黄体期雌二醇预处理在正常反应者中应用于促性腺激素释放激素拮抗剂方案前的疗效：一项系统评价与Meta分析
- Title En
- The efficacy of luteal estradiol pretreatment prior to the GnRH antagonist protocol in normal responders, a systemic review and meta-analysis.
- Bilingual Status
- complete