Meta AnalysisID 6694
黄芪类中药注射液联合铂类化疗治疗晚期非小细胞肺癌的临床有效性和安全性：随机对照试验的网状Meta分析
CRD42023457911
Are Astragalus-based Chinese medicine injections effective for advanced non-small cell lung cancer? What are the advantages of Astragalus-based Chinese medicine injections compared with platinum-based chemotherapy in the
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Formula: 1Meta-analysis: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 6694
- Evidence Id
- 15252
- Core Evidence Id
- 15252
- Source Meta Analysis Id
- 6675
- Herb2 Meta Analysis Id
- HBMA006675
- Crd Id
- CRD42023457911
- Title
- Clinical efficacy and safety of Astragalus-based Chinese herbal injections combined with platinum-based chemotherapy for advanced non-small cell lung cancer: a network meta-analysis of randomized control trials
- Review Question
- Are Astragalus-based Chinese medicine injections effective for advanced non-small cell lung cancer? What are the advantages of Astragalus-based Chinese medicine injections compared with platinum-based chemotherapy in the treatment of advanced non-small cell lung cancer?
- Study Type Included
- Randomized controlled trial
- Condition Being Studied
- Non-small cell lung cancer is the most common tumor of the chest. Platinum-containing chemotherapy is the most common treatment for patients with non-small cell lung cancer. However, platinum-based drugs can bring adverse events such as myelosuppression, nausea and vomiting, which affect their quality of life. Previous studies have shown that astragalus-based herbs combined with platinum-based chemotherapy can be efficacious and toxicity-reducing. However, there are many types of Chinese medicines and it is not clear which astragalus-based Chinese medicine has better efficacy and safety. The purpose of this study is to compare the efficacy and safety of five traditional Chinese medicine injections for the treatment of non-small cell lung cancer.
- Participant
- Patients with non-small cell lung cancer with a definitive pathologic or cytologic diagnosis and TNM imaging stage III-IV. There are no restrictions on their age, sex or race.
- Animal
- Human Disease Modelled
- Intervention
- Aidi Injection or Shenqi Fuzheng Injection or Kang'ai Injection or Astragalus Polysaccharide Injection or Huangqi Injection in combination with platinum-containing chemotherapy regimens.
- Comparator Control
- Placebo combined with a platinum-containing chemotherapy regimen or a platinum-containing chemotherapy regimen only.
- Main Outcome
- Objective response rate Measures of effect The total efficiency is dichotomous type data and the results of syntheses will be expressed as OR and 95% CI.
- Outcome Measure
- Additional Outcome
- Disease control rate, kps improvement rate, immune function (CD3+, CD4+, CD8+, CD4+/CD8+, NK), adverse events (leukopenia, nausea and vomiting, etc.) Measures of effect If the outcomes are continuous, the results of syntheses will be expressed as MD or SMD and 95% CI. If the outcomes are dichotomous, the results of syntheses will be expressed as OR and 95% CI.
- Study Method
- Intervention, Network meta-analysis, Systematic review
- Keyword
- Astragalus Plant; Carcinoma, Non-Small-Cell Lung; Humans; Lung Neoplasms; Medicine, Chinese Traditional; Platinum; Randomized Controlled Trials as Topic
- Contact
- Fei Liu [email protected]
- Organisational Affiliation
- Hebei Province Cangzhou Hospital of Integrated Traditional and Western Medicine http://www.hbsczzxy.com/
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-08-26
- Registration Date
- 2023-09-06
- Anticipated Start Date
- 2023-08-08
- Anticipated Completion Date
- 2024-01-01
- Title Cn
- 黄芪类中药注射液联合铂类化疗治疗晚期非小细胞肺癌的临床有效性和安全性：随机对照试验的网状Meta分析
- Title En
- Clinical efficacy and safety of Astragalus-based Chinese herbal injections combined with platinum-based chemotherapy for advanced non-small cell lung cancer: a network meta-analysis of randomized control trials
- Bilingual Status
- complete