Meta AnalysisID 666
蜂蜜作为抗氧化剂对实验研究中再灌注损伤的影响：一项系统评价
CRD42022289694
What is impact of honey as antioxidant on reperfusion injury in experimental studies? Context and rationale Reperfusion injury is a paradoxical exacerbation of cell dysfunction and death caused by reactive oxygen species
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Record Fields
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- Meta Analysis Id
- 666
- Evidence Id
- 9224
- Core Evidence Id
- 9224
- Source Meta Analysis Id
- 644
- Herb2 Meta Analysis Id
- HBMA000644
- Crd Id
- CRD42022289694
- Title
- Honey and its impact as antioxidant on reperfusion injury in experimental studies: a systematic review
- Review Question
- What is impact of honey as antioxidant on reperfusion injury in experimental studies? Context and rationale Reperfusion injury is a paradoxical exacerbation of cell dysfunction and death caused by reactive oxygen species (ROS) after restoration of blood flow to ischemic tissue. Reperfusion injury is associated with a variety of serious clinical manifestations, including acute heart failure, cerebral dysfunction, systemic inflammatory response syndrome, and multiple organ dysfunction syndrome. One way to prevent the reperfusion injury process is through chemical substances that inhibit or control the oxidation of substrates to overcome ROS, these substances are called antioxidants. Honey is a sweet liquid that comes from honey bees and is most often used as a sweetener. Honey is easy to find because it is produced in many countries around the world. Honey has phenolic acids and flavonoids which have been shown to have antioxidant effects. Honey contains phenolic acids in the form of galangin, luteolin, pinobanksin, hesperetin, and naringenin. While the phenolic acids contained in honey are gallic acid, ellagic acid, ferulic acid, and syringic acid. Phenolic acids and flavonoids are included in phenolic compounds that can reduce or inhibit free radicals by transferring hydrogen atoms, from their hydroxyl groups. The antioxidant properties of honey and 'easy to get' nature of honey are the reasons for this study. This study aims to determine the impact as antioxidant of honey on reperfusion injury in experimental studies.
- Study Type Included
- Inclusion criteria: For both human and animal studies: - Experimental study design Exclusion criteria: None
- Condition Being Studied
- Participant
- Animal
- Inclusion criteria: For human studies: - All human models (any sexes, any age, etc.) For animal studies: - All animal models (any species, any sexes, any age, etc.) Exclusion criteria: For both human and animal studies: - In silico models
- Human Disease Modelled
- Reperfusion injury or any pathological change(s) cause by it
- Intervention
- Inclusion criteria: For both human and animal studies:- All timings, frequencies and dosages of honey treatment are eligible for inclusion Exclusion criteria: For both human and animal studies:- Samples treated with bee products other than honey
- Comparator Control
- Inclusion criteria: For both human and animal studies: - All type of control conditions Exclusion criteria: No restriction
- Main Outcome
- Outcome Measure
- Inclusion criteria: For both human and animal studies: - Any outcome measures Exclusion criteria: For both human and animal studies: - No relevant outcomes related to impact of honey as antioxidant on reperfusion injury
- Additional Outcome
- Study Method
- Keyword
- Animals; Antioxidants; Honey; Reperfusion Injury
- Contact
- Ramadhani Hengki Wijaya [email protected]
- Organisational Affiliation
- Mulawarman University https://unmul.ac.id/
- Funding Source
- This research has no funding nor sponsors
- Other Selection Criteria
- For both human and animal studies: - No publication date restriction. - Original full research papers only. - Research papers in English and Indonesian languages only. - Research papers with no relevant aim related to impact of honey as antioxidant on reperfusion injury will be excluded. - All review papers will be excluded.
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Pre-clinical animal intervention review
- Language
- English
- Country
- Indonesia
- Review Stage
- Review Completed not published
- First Submission Date
- 2021-11-23
- Registration Date
- 2022-01-04
- Anticipated Start Date
- 2021-09-25
- Anticipated Completion Date
- 2022-05-31
- Title Cn
- 蜂蜜作为抗氧化剂对实验研究中再灌注损伤的影响：一项系统评价
- Title En
- Honey and its impact as antioxidant on reperfusion injury in experimental studies: a systematic review
- Bilingual Status
- complete