Meta AnalysisID 6648
三种常用中成药联合常规西药治疗非增殖性糖尿病视网膜病变的疗效与安全性：网状Meta分析
CRD42022371577
Which is more effective and safer to treat non-proliferative diabetic retinopathy with three commonly used proprietary Chinese medicines in combination with conventional Western medicines? A Network Meta-analysis.
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Record Fields
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- Meta Analysis Id
- 6648
- Evidence Id
- 15206
- Core Evidence Id
- 15206
- Source Meta Analysis Id
- 6631
- Herb2 Meta Analysis Id
- HBMA006631
- Crd Id
- CRD42022371577
- Title
- Efficacy and Safety of the Three Commonly Used Chinese Patent Medicines Combined with Conventional Western Medicine in Treating Non-Proliferative Diabetic Retinopathy: A Network Meta-analysis
- Review Question
- Which is more effective and safer to treat non-proliferative diabetic retinopathy with three commonly used proprietary Chinese medicines in combination with conventional Western medicines? A Network Meta-analysis.
- Study Type Included
- Randomized controlled trials, regardless of study geography, whether blinded or not, Chinese and English literature only.
- Condition Being Studied
- Diabetic retinopathy is now recognized as one of the serious diabetic microangiopathies. It is divided into non-proliferative and proliferative lesions according to whether neovascularization appears in the fundus. Once the disease progresses to PDR, the condition is serious and the treatment cost is high, so it is extremely important to actively take pharmacological treatment during the period of NPDR. In recent years, the application of Chinese medicine has made great progress in the treatment of NPDR, and Qiming granules, Fuxiang Danshen Dripping Pills and Fuxiang Thromboxylon Capsules, as three Chinese medicines commonly used in clinical practice, have remarkable efficacy. Therefore, the differences in the efficacy of different TCM drugs in the treatment of NPDP are compared and ranked by using the reticulated Meta-analysis method, in order to provide reference and evidence-based medical evidence to support the clinical optimization of drug selection.
- Participant
- Patients were required to be NPDR patients of all levels eligible for DR staging diagnosis, regardless of age, sex, occupation and region of origin.
- Animal
- Human Disease Modelled
- Intervention
- In the experimental group, Qiming granules, compound Danshen drops and compound thromboxane capsules were added to the conventional western medicine.
- Comparator Control
- Conventional western drugs for the treatment of NPDR
- Main Outcome
- Total effective rate, visual acuity, macular thickness, hemorrhagic spot area, hemangioma volume, visual field gray value, incidence of adverse effects
- Outcome Measure
- Additional Outcome
- Ultrasensitive C-reactive protein (hs-CRP)], vascular endothelial growth factor (VEGF), peak systolic flow velocity (PSV), end-diastolic flow velocity (EDV), flow resistance index (RI) and pulsatility index (PI), etc.
- Study Method
- Meta-analysis, Systematic review
- Keyword
- China; Diabetes Mellitus; Diabetic Retinopathy; Humans; Medicine, Chinese Traditional; Network Meta-Analysis; Nonprescription Drugs
- Contact
- Yijia Jiang [email protected]
- Organisational Affiliation
- Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China
- Funding Source
- the National administration of traditional Chinese medicine Young Qi Huang Scholars support project(National traditional Chinese medicine human education development [2020] No. 7） Grant number(s) <span style=font-size: 14px>State the funder, grant or award number and the date of award</span> National traditional Chinese medicine human education development [2020] No. 7
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-11-07
- Registration Date
- 2022-11-17
- Anticipated Start Date
- 2022-10-30
- Anticipated Completion Date
- 2022-12-06
- Title Cn
- 三种常用中成药联合常规西药治疗非增殖性糖尿病视网膜病变的疗效与安全性：网状Meta分析
- Title En
- Efficacy and Safety of the Three Commonly Used Chinese Patent Medicines Combined with Conventional Western Medicine in Treating Non-Proliferative Diabetic Retinopathy: A Network Meta-analysis
- Bilingual Status
- complete