Meta AnalysisID 6624
指南推荐的6种中成药联合生活方式干预治疗糖尿病前期的疗效比较：一项网状Meta分析
CRD42021273543
The aim of this meta-analysis of randomized controlled trials is to evaluate the efficacy and safety of 6 Traditional Chinese patent medicines recommended from guidelines combined with lifestyle modification in patients
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Record Fields
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- Meta Analysis Id
- 6624
- Evidence Id
- 15182
- Core Evidence Id
- 15182
- Source Meta Analysis Id
- 6604
- Herb2 Meta Analysis Id
- HBMA006604
- Crd Id
- CRD42021273543
- Title
- Comparative efficacy of 6 Traditional Chinese patent medicines recommended from guidelines combined with lifestyle modification in patients with prediabetes: A network meta-analysis
- Review Question
- The aim of this meta-analysis of randomized controlled trials is to evaluate the efficacy and safety of 6 Traditional Chinese patent medicines recommended from guidelines combined with lifestyle modification in patients with prediabetes.
- Study Type Included
- Randomized clinical trials will be included irrespective of blinding, publication status or language
- Condition Being Studied
- Prediabetes is an abnormal state of glucose metabolism between normal blood sugar and diabetes, including impaired fasting glucose(IFG) or impaired glucose tolerance(IGT)or both (IFG+IGT), which means that fasting blood glucose(FBG) and/or 2h postprandial blood glucose (PBG) in oral glucose tolerance test (OGTT) increase but do not meet the diagnostic criteria for diabetes. The latest data released by the International Diabetes Federation in 2019 showedthat 1 in 13 adults (20-79 years) had impaired glucose tolerance(374 million people) worldwide. It was estimated that the number of people with prediabetes could rise to 472 million by 2030. An epidemiological survey organized by Chinese Diabetes Society (CDS) in 2010 showed that the prevalence of prediabetes in China was 50.1%. The emergence of prediabetes will mark the increased risk of diabetes, cardiovascular and cerebrovascular diseases, microvascular diseases, tumors and dementia in the future . Timely detection and effective management of prediabetes are the key to prevent the occurrence of diabetes and its complications. Domestic and foreign diabetes guidelines and clinical practices mainly focus on health education, diet adjustment, regular exercise or drug intervention, but there are some shortcomings in patient compliance, long-term safety and health benefit.
- Participant
- We will include these type of participants: patients diagnosed with prediabetes(IFG+IGT)) either using WHO 2020 CDS Guidelines for the Prevention and Treatment of T2DM or 2020 American Diabetes Association diagnostic criteria. Race, age and gender were not limited. We will exclude these type of participants: pregnant and lactating patients
- Animal
- Human Disease Modelled
- Intervention
- Main intervention: The experimental group was treated with lifestyle modification combined with Traditional Chinese patent medicines, including Shen qi jiang tang capsule/granule/tablet, Tian mai xiao ke capsule/granule/table, Tian qi capsule/ granule/tablet, Jin qi jiang tang capsule/granule/table, Jin li dacapsule/granule/table, Tang mai kang capsule/granule/tablet.
- Comparator Control
- The control group was treated with oral hypoglycemic drugs or lifestyle modification.
- Main Outcome
- The primary outcomes included the ratio of converting to DM according to standard Western medicine diagnostic criteria by the end of the trial. Measures of effect odds ratio (OR) was used for counting data
- Outcome Measure
- Additional Outcome
- Secondary outcomes included ΔHbA1c,ΔFBG and ΔPBG. Measures of effect Standardized mean difference (SMD) was used for measurement data
- Study Method
- Network meta-analysis, Systematic review
- Keyword
- China; Humans; Life Style; Network Meta-Analysis; Nonprescription Drugs; Prediabetic State
- Contact
- Li Jiang [email protected]
- Organisational Affiliation
- Dongzhimen Hospital affiliated to Beijing University of Chinese Medicine, Beijing, China
- Funding Source
- This work was supported by Project for Young Teachers of Beijing University of Chinese Medicine(No.2019-JYB-JS-080), study on syndrome differentiation standard of Yin deficiency syndrome in type 2 diabetes mellitus(2018YFC1704402), Section II of Endocrinology & Nephropathy department of Dongzhimen Hospital affiliated to Beijing University of Chinese Medicine, and Key Laboratory of Chinese Internal Medicine of Ministry of Education. Grant number(s) <span style=font-size: 14px>State the funder, grant or award number and the date of award</span> Project for Young Teachers of Beijing University of Chinese Medicine(No.2019-JYB-JS-080) Study on syndrome differentiation standard of Yin deficiency syndrome in type 2 diabetes mellitus(2018YFC1704402),
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2021-08-14
- Registration Date
- 2021-09-14
- Anticipated Start Date
- 2021-08-14
- Anticipated Completion Date
- 2021-09-12
- Title Cn
- 指南推荐的6种中成药联合生活方式干预治疗糖尿病前期的疗效比较：一项网状Meta分析
- Title En
- Comparative efficacy of 6 Traditional Chinese patent medicines recommended from guidelines combined with lifestyle modification in patients with prediabetes: A network meta-analysis
- Bilingual Status
- complete