Meta AnalysisID 6601
参松养心胶囊治疗室性期前收缩的疗效和安全性：系统评价和Meta分析方案
CRD42022378985
The aim of this meta-analysis of randomized controlled trials is to evaluate the efficacy and safety of Shensong Yangxin capsule in the treatment of Premature Ventricular Complexes
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Record Fields
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- Meta Analysis Id
- 6601
- Evidence Id
- 15159
- Core Evidence Id
- 15159
- Source Meta Analysis Id
- 6612
- Herb2 Meta Analysis Id
- HBMA006612
- Crd Id
- CRD42022378985
- Title
- Efficacy and safety of Shensong Yangxin capsule in the treatment of Premature Ventricular Complexes ：A protocol for systematic review and meta-analysis
- Review Question
- The aim of this meta-analysis of randomized controlled trials is to evaluate the efficacy and safety of Shensong Yangxin capsule in the treatment of Premature Ventricular Complexes
- Study Type Included
- The study will include randomized controlled trials of SSYX in the treatment of PVCs, whether blind or not, in Chinese and English.
- Condition Being Studied
- Premature Ventricular Complexes (PVCs) are the contraction caused by early depolarization of ventricular muscles below his bundle and its branches. They are a common type of arrhythmia in the clinic. Studies have shown that frequent PVCs are closely associated with an increased risk of heart failure, cardiomyopathy, ventricular arrhythmia, sudden cardiac death and ischemic stroke. At present, the treatment of PVCs includes drug treatment and surgical treatment, which can reduce the frequency of PVCs in the heart with non-organic lesions, but may also cause side effects, such as gastroesophageal reflux, constipation and leg swelling. Recently, Several clinical research has proved that the SSYX can reduce the overall number of premature beats and alleviate PVC-related symptoms. At the same time, it can improve cardiac function to a certain extent for patients with heart failure, and it can partially increase the heart rate of patients with sinus bradycardia. However, the evidence from a single randomized controlled trial is relatively insufficient, and no relevant systematic review has been published. Therefore, we conducted a meta-analysis to evaluate the efficacy and safety of SSYX in the treatment of PVCs, providing a reference for clinical use.
- Participant
- Participants were diagnosed as PVCs. The diagnostic standard shall conform to the general diagnostic standard of WHO, or the reference standard formulated by the state, or the standard recommended by professional associations.
- Animal
- Human Disease Modelled
- Intervention
- The experimental group was treated with SSYX.
- Comparator Control
- the control group was treated with antiarrhythmic drugs or a placebo. including β-blockers and non-dihydropyridine calcium channel blockers, et al.
- Main Outcome
- Total number and frequency of PVCs.
- Outcome Measure
- Additional Outcome
- adverse reactions, safety indicators, symptom scores, ECG efficacy, and quality of life scores.
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Drugs, Chinese Herbal; Humans; Meta-Analysis as Topic; Randomized Controlled Trials as Topic; Systematic Reviews as Topic; Ventricular Premature Complexes
- Contact
- XiXi Zhai [email protected]
- Organisational Affiliation
- Shandong University of Traditional Chinese Medicine
- Funding Source
- This work was supported by the Key Technology Research and Development Program of Shandong (2021LCXZ06)
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-11-25
- Registration Date
- 2022-12-07
- Anticipated Start Date
- 2022-12-01
- Anticipated Completion Date
- 2023-06-01
- Title Cn
- 参松养心胶囊治疗室性期前收缩的疗效和安全性：系统评价和Meta分析方案
- Title En
- Efficacy and safety of Shensong Yangxin capsule in the treatment of Premature Ventricular Complexes ：A protocol for systematic review and meta-analysis
- Bilingual Status
- complete