Meta AnalysisID 66
草药败酱草治疗急性呼吸道感染的临床研究系统评价
CRD42021260330
This systematic review aims to evaluate the clinical effectiveness and safety of the herb Herba Patriniae in acute respiratory tract infections (ARTIs).
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 66
- Evidence Id
- 8624
- Core Evidence Id
- 8624
- Source Meta Analysis Id
- 61
- Herb2 Meta Analysis Id
- HBMA000061
- Crd Id
- CRD42021260330
- Title
- Herbal Medicine Patrinia herba for acute respiratory tract infections: a systematic review of clinical studies
- Review Question
- This systematic review aims to evaluate the clinical effectiveness and safety of the herb Herba Patriniae in acute respiratory tract infections (ARTIs).
- Study Type Included
- Randomized controlled trials (RCTs), clinical controlled trials (CCT), case-control studies, and cohort studies will be included.
- Condition Being Studied
- Acute respiratory tract infections (ARTIs).
- Participant
- Patients in all age groups will be included whether their diagnoses of ARTIs were confirmed or suspected. Diagnoses include common cold, influenza, rhinosinusitis, laryngitis, tonsillitis, pharyngitis, croup, acute otitis media, bronchitis, pneumonia, and acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Symptoms of suspected ARTIs including cough, sore throat, fever, runny nose, and discoloured sputum for a duration of equal or fewer than four weeks. Any life-threatening condition will be excluded. Participants who were clearly diagnosed chronic without infection or reported vaguely on whether were infected or not will be excluded.
- Animal
- Human Disease Modelled
- Intervention
- Herbal medicine Patrinia herba (Bai Jiang Cao), either as a single herb or a herbal mixture, presented in any form of preparations, e.g. decoctions, granules, injections, paste, pills, and steam, provided with or without conventional therapies. There will be no limitation concerning the dosage, dose administrated, or the course of the treatment.
- Comparator Control
- Placebo, no treatment, waiting list control; usual care such as antipyretics, antivirals, antibiotics, anti-inflammatories, steroids or corticosteroids will be included.
- Main Outcome
- Symptom improvement -Time to complete resolution of systemic symptoms (in days), or proportion of patients resolved at a predefined time. The following symptoms were expected to be of primary interest (key symptoms): fever and pain all over the body. -Time to complete resolution of respiratory symptoms (in days), or proportion of patients with key symptoms resolved at a predefined time. The following symptoms were expected to be of primary interest (key symptoms): runny nose, cough and sore throat.
- Outcome Measure
- Additional Outcome
- 1. Changes in the use of antibiotic, e.g. dose, duration, or the form of antibiotics. 2. (Proportion of participants with) Days off work or school due to ARTIs or acute exacerbation of ARTIs. 3.vProportion of participants who need to be admitted to hospital; length of hospitalization. 1. Adverse events (AEs) (any anaphylactic, allergic reactions, hypersensitivity reactions, or complications that were resulted from Patrinia herba, and any herbal-drug interactions will be collected) Serious AEs will be defined according to the International Council on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) guidelines as follows: 1. Any event that leads to death, is life-threatening, requires hospitalisation, or leads to persistent or significant disability. 2. Abnormal vital signs and abnormal physical observations results such as electrolytes, liver, and kidney function tests (alanine aminotransferase and creatinine).
- Study Method
- Intervention, Meta-analysis, Systematic review
- Keyword
- Herbal Medicine; Humans; Patrinia; Phytotherapy; Plants, Medicinal; Respiratory Tract Infections
- Contact
- Jianping Liu [email protected]
- Organisational Affiliation
- Center for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine Primary Care, Population Science and Medical Education, University of Southampton
- Funding Source
- This review is funded by Innovate UK (grant no. 104287-610239) and the National Key Research and Development Project (grant no. 2018YFE0102300) Grant number(s) <span style=font-size: 14px>State the funder, grant or award number and the date of award</span>
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China, England
- Review Stage
- Review Ongoing
- First Submission Date
- 2021-06-10
- Registration Date
- 2021-07-21
- Anticipated Start Date
- 2021-06-01
- Anticipated Completion Date
- 2021-12-31
- Title Cn
- 草药败酱草治疗急性呼吸道感染的临床研究系统评价
- Title En
- Herbal Medicine Patrinia herba for acute respiratory tract infections: a systematic review of clinical studies
- Bilingual Status
- complete