Meta AnalysisID 6407
舒血宁注射液治疗不稳定型心绞痛的有效性和安全性的系统评价和序贯分析
CRD42021223531
Most clinical studies of TRADITIONAL Chinese medicine only stay at the stage of summarizing clinical experience, lacking prospective studies with large sample size, and their pharmacological active components and pharmac
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- Meta Analysis Id
- 6407
- Evidence Id
- 14965
- Core Evidence Id
- 14965
- Source Meta Analysis Id
- 6391
- Herb2 Meta Analysis Id
- HBMA006391
- Crd Id
- CRD42021223531
- Title
- Systematic evaluation and sequential analysis of the efficacy and safety of Shuxuening injection in the treatment of unstable angina
- Review Question
- Most clinical studies of TRADITIONAL Chinese medicine only stay at the stage of summarizing clinical experience, lacking prospective studies with large sample size, and their pharmacological active components and pharmacological mechanism still need further study. In this study, the efficacy and safety of Shuxueling injection combined with conventional western medicine in the treatment of unstable angina pectoris were systematically evaluated to objectively evaluate the clinical efficacy of Shuxueling injection.
- Study Type Included
- A randomized controlled trial of Shuxuening injection combined with conventional Western medicine in the treatment of unstable angina pectoris
- Condition Being Studied
- Unstable angina (UA) is an acute coronary syndrome between stable angina pectoris and acute myocardial infarction, which is mainly manifested as pain in the anterior cardiac region and posterior sternum. Its instability is mainly affected by local coronary artery lesions, characterized by progressive exacerbation of angina symptoms and prolonged duration of pain.Thrombus formation is mainly caused by rupture of atherosclerotic plaques or erosion of the mural walls in coronary arteries.The effective treatment of unstable angina can improve the survival rate and quality of life of the patients. Western medicine treatment mainly includes stable plaque, the use of anti-platelet and anti-thrombotic drugs, the reduction of myocardial injury caused by ischemia and reperfusion, and the prevention of the progression of coronary atherosclerosis
- Participant
- 1，According to the guidelines for the Rapid Diagnosis and Treatment of Acute Coronary Syndromes (2019), the diagnostic criteria for midteratoform angina are acceptable. Age, sex, alcohol and tobacco history and other conditions are not restricted. 2，The intervention measures did not meet the standard, the diagnosis was not clear, and the treatment process was not clear. In the experimental group, except for segmentation, only Shu Xueling injection or Western medicine was used, but no proprietary Chinese medicine was used. , the result index has no other content except adverse reaction.
- Animal
- Human Disease Modelled
- Intervention
- 治疗组采用舒雪灵注射液联合常规西药治疗。
- Comparator Control
- The control group only received the same conventional western medicine treatment, the main drugs were anticoagulation, anti-platelet aggregation, -blockers, nitrates, angiotensin-converting enzyme inhibitors (ACEI), statins and other lipid-lowering drugs
- Main Outcome
- Effect of electrocardiogram:The efficacy of electrocardiogram was examined before and after treatment in the 2 groups. The evaluation criteria of the efficacy of electrocardiogram were as follows: Significant effect: st-T of resting electrocardiogram returned to normal or roughly normal;(2) Effective: static ELECTROcardiogram ST segment depression, after treatment rise more than 0.05 mm, but not to the normal level, or the main lead inverted T-wave shallow more than 50% or from flat to upright T wave;(3) No effect: The rest ELECTROcardiogram ST-T was approximately the same as before treatment；The total effective rate was calculated by the obvious effect + effective effect；Nitroglycerin dosage a dose used in one week；Duration of angina: The duration of symptoms and signs of each angina attack；Angina frequency: number of angina attacks per day Measures of effect The main indicators were angina frequency, duration of angina, nitroglycerin dosage, and ecg improvement
- Outcome Measure
- Additional Outcome
- Clinical curative effect：Symptoms such as shortness of breath, palpitation and chest tightness disappeared completely, and the number of angina attacks decreased by more than 80%. The above symptoms were improved to a certain extent, and the reduction of the number of angina attacks between 50% and 80% was effective.No improvement or even aggravation of the above symptoms, and a reduction of less than 50% in the number of angina attacks was not effective.Serum BNP and HS-CRP were determined by enzyme-linked immunosorbent assay (ELISA) before and after treatment；Adverse reactions：Observe for signs of allergies；Blood lipids were determined by chemical and leaven methods Measures of effect Secondary indicators were clinical efficacy of angina, blood lipids (triglycerides, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol), C-reactive protein, BNP (brain natriuretic peptide), adverse drug reactions or adverse events
- Study Method
- 系统评价
- Keyword
- Angina, Unstable; Drugs, Chinese Herbal; Humans; shuxuening
- Contact
- yongxia wang [email protected]
- Organisational Affiliation
- The first Affiliated Hospital of Henan University of Chinese Medicine
- Funding Source
- 1、Ministry of Science and Technology management of the national key basic research development program, the national high technology research and development, national science and technology support plan, international technology cooperation and communication projects, the National Development and Reform Commission, ministry of joint management of the industrial technology research and development fund, the ministry of agriculture, management of public welfare industry health development planning commission and other 13 department scientific research projects, etc., integrated to form a national key research and development plan. 2、The National Administration of Traditional Chinese Medicine is the national administration under the administration of the National Health Commission Grant number(s) <span style=font-size: 14px>State the funder, grant or award number and the date of award</span> This work is supported by the National Key Research and Development Program(2018YFC1707402;2019YFC1710005) and Chinese Medicine Evidence-based Capacity Building Project of State Administration of Traditional Chinese Medicine(2019XZZX-XXG003)
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2021-01-22
- Registration Date
- 2021-02-22
- Anticipated Start Date
- 2020-10-01
- Anticipated Completion Date
- 2021-02-24
- Title Cn
- 舒血宁注射液治疗不稳定型心绞痛的有效性和安全性的系统评价和序贯分析
- Title En
- Systematic evaluation and sequential analysis of the efficacy and safety of Shuxuening injection in the treatment of unstable angina
- Bilingual Status
- complete