Meta AnalysisID 6356
8种中成药联合常规西药治疗早期慢性肾脏病的临床疗效与安全性：网状Meta分析
CRD42023388981
Clinical efficacy, safety of eight Chinese patent medicines combined with conventional western medicine treatment in the treatment of early chronic kidney disease P: early chronic kidney disease I: eight Chinese patent
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Record Fields
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- Meta Analysis Id
- 6356
- Evidence Id
- 14914
- Core Evidence Id
- 14914
- Source Meta Analysis Id
- 6365
- Herb2 Meta Analysis Id
- HBMA006365
- Crd Id
- CRD42023388981
- Title
- Clinical efficacy, safety of eight Chinese patent medicines combined with conventional western medicine treatment in the treatment of early chronic kidney disease: A network meta-analysis.
- Review Question
- Clinical efficacy, safety of eight Chinese patent medicines combined with conventional western medicine treatment in the treatment of early chronic kidney disease P: early chronic kidney disease I: eight Chinese patent medicines C: conventional western medicine O: Clinical efficacy and safety S: RCT
- Study Type Included
- RCT
- Condition Being Studied
- Chronic kidney disease ( CKD ) has the characteristics of high prevalence, low awareness, poor prognosis and high medical expenses. It is a disease that seriously endangers human health in addition to cardiovascular and cerebrovascular diseases, diabetes and malignant tumors. In recent years, the prevalence of CKD has increased year by year. The prevalence of CKD in the global general population has reached 14.3 % . China 's cross-sectional epidemiological survey shows that the prevalence of CKD in people over 18 years old is 10.8 %. As China 's population aging and the incidence of diabetes, hypertension and other diseases increased year by year, the incidence of CKD is also rising trend.Patients with chronic kidney disease may show no obvious discomfort before CKD3, or only show atypical symptoms such as fatigue, anorexia, nocturia, low back pain, hematuria, etc. After CKD3, the above symptoms often progress rapidly, with a series of uremia symptoms such as anemia, metabolic acidosis, and hyperkalemia. Therefore, we try to evaluate the effect of traditional Chinese medicine on early chronic kidney disease in order to find a new method to delay the progression of renal function.
- Participant
- Patients who were diagnosed with early CKD were included. Early CKD was defined as eGFR ≥30 mL/ (min×1.73 m2） or Scr <442μmol/L.
- Animal
- Human Disease Modelled
- Intervention
- 8 CPMS(Shenyan Kangfu Tablet、NIAODUQING granule、Yishen Huashi granule、Bailing Capsule、Tripterygium glycosides、Huangkui Capsule、Kunxian Capsule、Jinshuibao)
- Comparator Control
- Conventional western medicine treatment
- Main Outcome
- The primary outcome was eGFR that the mean change from baseline.
- Outcome Measure
- Additional Outcome
- The secondary outcomes included 24-h urinary total protein (24-h UTP), SCr, blood urea nitrogen (BUN) that the mean change from baseline. Safety outcomes included any adverse events (AEs)
- Study Method
- Network meta-analysis, Systematic review
- Keyword
- Humans; Medicine, Chinese Traditional; Network Meta-Analysis; Nonprescription Drugs; Randomized Controlled Trials as Topic; Renal Insufficiency, Chronic; Treatment Outcome
- Contact
- Xuemei Gong [email protected]
- Organisational Affiliation
- Sichuan university none
- Funding Source
- Fu Ping, West China Hospital of Sichuan University
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-01-03
- Registration Date
- 2023-01-14
- Anticipated Start Date
- 2022-12-30
- Anticipated Completion Date
- 2023-03-30
- Title Cn
- 8种中成药联合常规西药治疗早期慢性肾脏病的临床疗效与安全性：网状Meta分析
- Title En
- Clinical efficacy, safety of eight Chinese patent medicines combined with conventional western medicine treatment in the treatment of early chronic kidney disease: A network meta-analysis.
- Bilingual Status
- complete