Meta AnalysisID 6317
中草药配方芪苈强心胶囊治疗心力衰竭：随机临床试验的系统评价与Meta分析
CRD42013006106
The objective of this review is to evaluate, from randomized clinical trials, the benefits and harms of Chinese herbal formula Qili Qiangxin for the treatment of heart failure.
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Record Fields
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- Meta Analysis Id
- 6317
- Evidence Id
- 14875
- Core Evidence Id
- 14875
- Source Meta Analysis Id
- 6302
- Herb2 Meta Analysis Id
- HBMA006302
- Crd Id
- CRD42013006106
- Title
- Chinese herbal formula Qili Qiangxin for heart failure: a systematic review and meta-analysis of randomized clinical trials
- Review Question
- The objective of this review is to evaluate, from randomized clinical trials, the benefits and harms of Chinese herbal formula Qili Qiangxin for the treatment of heart failure.
- Study Type Included
- Parallel-group, randomized clinical trials with regardless of blinding or publication types.
- Condition Being Studied
- Heart failure is defined as a complex clinical syndrome that results from any structural or functional impairment of ventricular filling or ejection of blood. The cardinal manifestations of heart failure are dyspnea and fatigue, which may limit exercise tolerance, and fluid retention, which may lead to pulmonary and/or splanchnic congestion and/or peripheral edema. There is no single diagnostic test for heart failure because it is largely a clinical diagnosis based on a careful history and physical examination (Yancy, Jessup et al. 2013)
- Participant
- Participants with all types of heart failure regardless of gender, age, etiology, ethnic group, severity, and course of disease, diagnosed with specific criteria (i.e. mention any one of criteria for diagnosis of heart failure) are eligible for inclusion.
- Animal
- Human Disease Modelled
- Intervention
- Chinese herbal formula Qili Qiangxin including all dosage or forms such as capsules, granules, or injection, as adjunctive therapy to conventional therapy. Qili Qiangxin formula is composed of 11 herbs (including Astragali radix, Ginseng radix et rhizoma, Aconiti lateralis radix preparata, Salvia miltiorrhiza radix et rhizoma, Semen descurainiae lepidii, Alismatis rhizoma, Polygonati odorati rhizoma, Cinnamomi ramulus, Carthami flos, Periploca cortex, and Citri reticulatae pericarpium).
- Comparator Control
- Placebo or no intervention in addition to conventional therapy. Trials with any other Chinese herbal medicine in control group will be excluded.
- Main Outcome
- All-cause mortality or cardiovascular mortality. Hospitalizations due to heart failure Major cardiovascular events
- Outcome Measure
- Additional Outcome
- Quality of life (QOL) measured by Minnesota Living with Heart Failure Questionnaire (MLHFQ). NYHA functional classification; Echocardiography measurements; 6-min walking distance (6MWD); Plasma amino-terminal pro-brain natriuretic peptide (NT-pro-BNP) Adverse events.
- Study Method
- Intervention, Meta-analysis
- Keyword
- Drugs, Chinese Herbal; Heart Failure; Humans
- Contact
- Miss. Jin Sun [email protected]
- Organisational Affiliation
- Center for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine http://www.bucm.edu.cn
- Funding Source
- The Program for Innovative Research Team (2011-CXTD-09) of Beijing University of Chinese Medicine, and the grant number 2011ZX09302-006-01-03(5) from the Ministry of Science and Technology of China.
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- Registration Date
- 2013-10-28
- Anticipated Start Date
- 2013-10-12
- Anticipated Completion Date
- 2013-11-30
- Title Cn
- 中草药配方芪苈强心胶囊治疗心力衰竭：随机临床试验的系统评价与Meta分析
- Title En
- Chinese herbal formula Qili Qiangxin for heart failure: a systematic review and meta-analysis of randomized clinical trials
- Bilingual Status
- complete