Meta AnalysisID 627
玉米须及其分离化合物的潜在神经保护作用：一项系统评价
CRD42022324368
What are the effects of Stigma maydis in preclinical models of neuroprotection? Context and rationale Neurodegenerative diseases encompass several diseases that affect the nervous system, such as Alzheimer's and Parkinso
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Record Fields
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- Meta Analysis Id
- 627
- Evidence Id
- 9185
- Core Evidence Id
- 9185
- Source Meta Analysis Id
- 602
- Herb2 Meta Analysis Id
- HBMA000602
- Crd Id
- CRD42022324368
- Title
- Potential neuroprotective effect of corn silk (Stigma maydis) and their isolated compounds: a systematic review
- Review Question
- What are the effects of Stigma maydis in preclinical models of neuroprotection? Context and rationale Neurodegenerative diseases encompass several diseases that affect the nervous system, such as Alzheimer's and Parkinson's disease. They have a complex pathophysiology involving several factors, such as oxidative stress and enzymatic activity. In this sense, plant-derived bioactive compounds have been studied as a possible therapeutic. Among these, maize stigmas (Stigma maydis) stand out for their bioactive compounds. Our aim was to perform a systematic review of studies that analysed neuroprotective effects of S. maydis.
- Study Type Included
- Inclusion criteria: Preclinical studies Exclusion criteria: Clinical studies, reviews
- Condition Being Studied
- Participant
- Animal
- Inclusion criteria: (1) Animals with induced neurodegenerative disease (2) Studies with rodents (3) Male and famale Exclusion criteria: (1) Non-mammalian models of the disease (e.g., Drosophila, zebra fish) (2) Animals with co-morbidities
- Human Disease Modelled
- Neurodegenerative diseases (Alzheimer's and Parkinson Diseases)
- Intervention
- Inclusion criteria: Stigma maydis extracts or isolated compounds found in this sample. In animal studies, studies that evaluated oral dosage will be added. In studies with cells, studies that evaluated the direct addition of the extract or isolated compounds in mechanisms related to neurodegenerative diseases were added. Exclusion criteria: There are no restrictions on duration, route of administration, dose or in vivo disease induction mechanism.
- Comparator Control
- Inclusion criteria: Treatment should be compared with an untreated control. Exclusion criteria: Studies that did not show a healthy control and a sick control.
- Main Outcome
- Outcome Measure
- Inclusion criteria: Assays of mediators of inflammation, proteins related to neurodegenerative diseases, action of antioxidant enzymes, improvement of the general picture of the neurological disease. Exclusion criteria: Data not related to neurological diseases or no relevant.
- Additional Outcome
- Study Method
- Keyword
- Animals; Flowers; Neuroprotective Agents; Plant Extracts; Silk; Zea mays
- Contact
- Daniel Alves de Souza [email protected]
- Organisational Affiliation
- Universidade Federal de Sergipe - UFS
- Funding Source
- Daniel Souza is a doctoral student at the Postgraduate Program in Physiological Sciences - UFS. Vitória Barbosa is a Master's student in the Postgraduate Program in Nutrition Sciences. Enilton Camargo and Elma Wartha are undergraduate and graduate professors at UFS. The Foundation for Support to Research and Technological Innovation of the State of Sergipe (FAPITEC/SE) finances this research through a doctoral scholarship provided to doctoral student Daniel Souza.
- Other Selection Criteria
- Review studies, book chapters, clinical studies, studies without abstract or that were not peer-reviewed will be excluded. There is no limitation by publication date or language.
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Pre-clinical animal intervention review
- Language
- English
- Country
- Brazil
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-04-09
- Registration Date
- 2022-06-28
- Anticipated Start Date
- 2022-04-11
- Anticipated Completion Date
- 2022-08-11
- Title Cn
- 玉米须及其分离化合物的潜在神经保护作用：一项系统评价
- Title En
- Potential neuroprotective effect of corn silk (Stigma maydis) and their isolated compounds: a systematic review
- Bilingual Status
- complete