Meta AnalysisID 623
印楝（印度楝）作为治疗痤疮潜在替代方法的有效性：随机对照试验的系统评价与Meta分析
CRD42022359779
In Adolescents (>= 12 years), adults (>= 18 years), male and female with acne or are suseptible to acne what is the effect of Azadirachta Indica/Neem (either from leave, fruits, bark or other parts), topical or ora
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 623
- Evidence Id
- 9181
- Core Evidence Id
- 9181
- Source Meta Analysis Id
- 597
- Herb2 Meta Analysis Id
- HBMA000597
- Crd Id
- CRD42022359779
- Title
- Azadirachta Indica (Neem) a potential alternative for the treatment of acne: A systematic review and Meta analysis of Randomized controlled trial
- Review Question
- In Adolescents (>= 12 years), adults (>= 18 years), male and female with acne or are suseptible to acne what is the effect of Azadirachta Indica/Neem (either from leave, fruits, bark or other parts), topical or oral formulation, with other pharmaceutical active or herbal constituents applied or ingested in humans. When compared with different composition or formulation of Neem, placebo, and other active treatment. Resulting in improvement or no new appearence of inflammatory and non-inflammatory acne lesions, comedones, papules, pustules, erythema, nodules, and itching, skin hydration, and reduction in sebum concentration (Primary outcome) or any adverse event (Secondary outcome). This will include published data from clinical trial (including adaptive clinical trial, RCT, phase trial, controlled clinical trial), from 1 st January 2012 to 1st January 2022 (10 years).
- Study Type Included
- Inclusion: Only studies reporting randomized control trials will be included in the study. Exclusion: Non-RCT, Pre clinical trials, case report, case series, SRMA, note, letter to editor, observational study
- Condition Being Studied
- As one of the most prevalent dermatological conditions, which affects teenagers and young adults, is a long-term inflammatory disorder of the pilosebaceous unit. Although acne is often a self-limiting problem, in its most extreme form, it can leave scars and discoloration within the skin. This may influence quaility of life, and may lead to mental disorder in people affected with the condition. Although many therapies are available for its treatment, ranging from antibiotics, hormonal therapy, corticosteroids, but this leads to adverse events and can be toxic.
- Participant
- Inclusion: Adolescents (>= 12 years), adults (>= 18 years), male and female with acne or suseptible to acne. Exclusion: Animal study, In-vitro study,
- Animal
- Human Disease Modelled
- Intervention
- Inclusion: Extract or active constituents of Azadirachta Indica/Neem (either from leave, fruits, bark or other parts), topical or oral formulation, with other pharmaceutical active or herbal constituents applied or ingested in humans. Exclusion: Formulation/s not containing neem extract or active constituents
- Comparator Control
- Inclusion: Different composition or formulation of Neem, placebo, and other active treatment.
- Main Outcome
- Improvement or no new appearence of inflammatory and non-inflammatory acne lesions, comedones, papules, pustules, erythema, nodules, and itching, skin hydration, and reduction in sebum concentration. This will be measured as mean change from baseline to endline, with either SD or 95% CI. Measures of effect Odds ratios
- Outcome Measure
- Additional Outcome
- Adverse events, serious adverse events or adverse events leading to discontinuation. Measures of effect Relative risks
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Acne Vulgaris; Adolescent; Adult; Azadirachta; Erythema; Female; Fruit; Humans; Male; Pharmaceutical Preparations; Plant Bark; Pruritus; Randomized Controlled Trials as Topic; Sebum
- Contact
- SHUBHAM SHARMA [email protected]
- Organisational Affiliation
- MarksMan Healthcare Communications Pvt. Ltd. http://marksmanhealthcare.com
- Funding Source
- None Grant number(s) <span style=font-size: 14px>State the funder, grant or award number and the date of award</span> None
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- India
- Review Stage
- Review Completed not published
- First Submission Date
- 2022-09-12
- Registration Date
- 2022-09-23
- Anticipated Start Date
- 2022-09-12
- Anticipated Completion Date
- 2023-02-28
- Title Cn
- 印楝（印度楝）作为治疗痤疮潜在替代方法的有效性：随机对照试验的系统评价与Meta分析
- Title En
- Azadirachta Indica (Neem) a potential alternative for the treatment of acne: A systematic review and Meta analysis of Randomized controlled trial
- Bilingual Status
- complete