Meta AnalysisID 620
益母草注射液预防人工流产妇女子宫出血：一项随机证据的系统评价与Meta分析
CRD42021274153
This aim of this meta-analysis of randomized controlled trials is to access the effectiveness and safety of motherwort injection alone or combined with oxytocin for preventing uterine hemorrhage in women with induced abo
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 620
- Evidence Id
- 9178
- Core Evidence Id
- 9178
- Source Meta Analysis Id
- 594
- Herb2 Meta Analysis Id
- HBMA000594
- Crd Id
- CRD42021274153
- Title
- Motherwort injection for preventing uterine hemorrhage in women with induced abortion： A systematic review and meta-analysis of randomized evidence
- Review Question
- This aim of this meta-analysis of randomized controlled trials is to access the effectiveness and safety of motherwort injection alone or combined with oxytocin for preventing uterine hemorrhage in women with induced abortion.
- Study Type Included
- Randomized controlled trials
- Condition Being Studied
- Approximately 205 million pregnancies occur each year worldwide. Over a third are unintended and about a fifth end in induced abortion. Insufficiency of induced abortion is a major cause of maternal death, especially in the developing world. Uterine insufficiency is the most risk factor for the insufficiency of induced abortion. The clinical manifestations include some symptoms such as prolonged postoperative bleeding, massive bleeding, and soreness in the waist and knees. Therefore, in clinical practice, we often use oxytocin to prevent this from happening.
- Participant
- Inclusion criteria： Patients who need to terminate their pregnancy within 10 weeks of pregnancy Exclusion criteria： Patients with ovarian cysts and uterine fibroids; Patients with liver and kidney dysfunction； Patients with cardiopulmonary insufficiency； Patients with failed abortion
- Animal
- Human Disease Modelled
- Intervention
- Motherwort injection alone or Motherwort injection combined with oxytocin
- Comparator Control
- Oxytocin alone
- Main Outcome
- 1. Duration of uterine hemorrhage: the number of days from the day of the induced abortion to the complete cessation of vaginal hemorrhage. 2. Volume of Uterine hemorrhage: It is the comparison between postoperative uterine hemorrhage volume and normal menstrual volume before pregnancy. The amount is recorded in ML as a unit of measurement. 3. The occurrence of adverse reactions. 4. Recovery time of normal menstruation: the time when the first menstruation regained after artificial abortion, including date, volume, and color. 5. Endometrial thickness Measures of effect We will calculate dichotomous data as rate ratios (RRs) with 95% confidence intervals (CIs) and continuous data as mean differences (MDs) with 95% CIs.
- Outcome Measure
- Additional Outcome
- Study Method
- Intervention, Meta-analysis, Systematic review
- Keyword
- Abortion, Induced; Female; Humans; Leonurus; Pregnancy; Uterine Hemorrhage
- Contact
- Xue Xinyu [email protected]
- Organisational Affiliation
- West China hospital, Sichuan University
- Funding Source
- The study will be supported by Chengdu No.1 Pharmaceutical Co Ltd. The funders have no involvement in study design
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2021-08-23
- Registration Date
- 2021-09-24
- Anticipated Start Date
- 2021-09-01
- Anticipated Completion Date
- 2022-11-01
- Title Cn
- 益母草注射液预防人工流产妇女子宫出血：一项随机证据的系统评价与Meta分析
- Title En
- Motherwort injection for preventing uterine hemorrhage in women with induced abortion： A systematic review and meta-analysis of randomized evidence
- Bilingual Status
- complete