Meta AnalysisID 604
评估常春藤叶治疗急性上呼吸道感染有效性的临床试验系统评价：更新
CRD42019141405
What is the effectiveness and tolerability of ivy leaf (Hedera Helix) in the treatment of acute upper respiratory tract infections in the adult and pediatric population?
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 604
- Evidence Id
- 9162
- Core Evidence Id
- 9162
- Source Meta Analysis Id
- 581
- Herb2 Meta Analysis Id
- HBMA000581
- Crd Id
- CRD42019141405
- Title
- Systematic review of clinical trials assessing the effectiveness of ivy leaf (hedera helix) for acute upper respiratory tract infections: an update
- Review Question
- What is the effectiveness and tolerability of ivy leaf (Hedera Helix) in the treatment of acute upper respiratory tract infections in the adult and pediatric population?
- Study Type Included
- Randomized controlled trials (RCTs), controlled clinical trials (CCTs), non-controlled observational studies (OSs) will be included. Studies to be excluded will be those without an explicit study design or method, as well as cross-sectional studies, therapy guidelines, and reviews.
- Condition Being Studied
- Acute upper respiratory tract infections including acute bronchitis.
- Participant
- Adults and pediatric populations with respiratory symptoms such as cough caused by upper respiratory tract infections (URTIs) including bronchitis. No specific age groups will be excluded. We will exclude studies that investigate patients with other acute diseases such as pertussis, pneumonia, or chronic upper respiratory tract diseases such as chronic obstructive pulmonary disease and asthma. However, we will not exclude studies if the majority of study subjects had URTIs or if treatment results were reported separately.
- Animal
- Human Disease Modelled
- Intervention
- Therapies with herbal expectorants containing ivy leaf (Hedera Helix) either as a single agent or in combination with other herbal agents will be investigated. All dosages will be included. Only oral or rectal forms of administration will be included.
- Comparator Control
- Included studies will contain a comparison to placebo, conventional expectorants (e.g., acetylcysteine), or other herbal therapies. Where other inclusion criteria are met, observational studies without a control group will also be included.
- Main Outcome
- Clinical outcomes such as morbidity, mortality, health-related quality of life measured by any instrument; surrogate values such as spirometric parameters (e.g., pulmonary function tests, lung volumes) measured before and after intervention; physical examination findings (e.g., auscultation, percussion) by physicians; assessment of symptoms such as cough by either physician or patient; assessment of tolerability (e.g., undesired side effects, hypersensitivity reactions) by either physician or patient. Measures of effect Outcomes will be assessed before and after therapy with an ivy leaf formulation.
- Outcome Measure
- Additional Outcome
- None Measures of effect Not applicable
- Study Method
- Systematic review
- Keyword
- Hedera; Humans; Plant Extracts; Respiratory Tract Infections
- Contact
- Elizabeth Sierocinski [email protected]
- Organisational Affiliation
- University of Greifswald https://www.uni-greifswald.de/en/
- Funding Source
- University of Greifswald
- Other Selection Criteria
- Final Publication
- Sierocinski E, Holzinger F, Chenot JF. Ivy leaf (Hedera helix) for acute upper respiratory tract infections: an updated systematic review. Eur J Clin Pharmacol. 2021. https://link.springer.com/article/10.1007/s00228-021-03090-4
- Same Topic Review
- This review is an update of our systematic review published in 2011: Felix Holzinger and Jean-François Chenot, “Systematic Review of Clinical Trials Assessing the Effectiveness of Ivy Leaf (Hedera Helix) for Acute Upper Respiratory Tract Infections,” Evidence-Based Complementary and Alternative Medicine, vol. 2011, Article ID 382789, 9 pages, 2011. https://doi.org/10.1155/2011/382789.
- Published Protocol
- Review Type
- Language
- English
- Country
- Germany
- Review Stage
- Review Completed published
- First Submission Date
- 2019-07-10
- Registration Date
- 2019-10-02
- Anticipated Start Date
- 2019-07-15
- Anticipated Completion Date
- 2020-06-08
- Title Cn
- 评估常春藤叶治疗急性上呼吸道感染有效性的临床试验系统评价：更新
- Title En
- Systematic review of clinical trials assessing the effectiveness of ivy leaf (hedera helix) for acute upper respiratory tract infections: an update
- Bilingual Status
- complete