Meta AnalysisID 6025
当归拈痛汤治疗痛风患者的有效性与安全性：系统评价与Meta分析
CRD42021271607
Is Danggui niantong decoction beneficial and safe for patients with gout?
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Record Fields
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- Meta Analysis Id
- 6025
- Evidence Id
- 14583
- Core Evidence Id
- 14583
- Source Meta Analysis Id
- 6008
- Herb2 Meta Analysis Id
- HBMA006008
- Crd Id
- CRD42021271607
- Title
- Efficacy and safety of Danggui niantong decoction in patients with gout: A systematic review and meta-analysis.
- Review Question
- Is Danggui niantong decoction beneficial and safe for patients with gout?
- Study Type Included
- Randomized controlled trials.
- Condition Being Studied
- Gout is a chronic inflammatory arthritis characterized by hyperuricemia and sodium urate deposition. Epidemiological evidence indicates that the incidence of gout in developed countries is about 4%, and has a rising trend. More and more reports show that gout can not only cause kidney diseases and joint damage, but also is closely related to severe diseases such as hypertension, diabetes, atherosclerosis, and coronary heart disease, seriously affecting the quality of life of patients. At present, nonsteroidal anti-inflammatory drugs and colchicine are still the most commonly used drugs for clinical treatment of gout. However, long-term use of these drugs may lead to some annoying side effects, including gastrointestinal ulcers, skin rash, osteoporosis, and so on. Therefore, it is urgent to find more reliable and low-toxicity alternative treatment strategies for gout. Danggui niantong decoction, first recorded in The Origin of Medicine, is one of the classical prescriptions for the treatment of gout. A series of clinical studies have reported that Danggui niantong decoction can effectively improve the clinical symptoms and related indicators of patients with gout, but there is no systematic review or meta-analysis to evaluate the efficacy of Danggui niantong decoction and verify whether it is an ideal alternative therapy.
- Participant
- Adult patients with a confirmed diagnosis of gout.
- Animal
- Human Disease Modelled
- Intervention
- Danggui niantong decoction is used orally, including decoction, pills, granules, and other forms.
- Comparator Control
- Control group: blank control group, placebo, conventional drugs.
- Main Outcome
- Pain intensity, pain duration, total effective rate, and serum uric acid level.
- Outcome Measure
- Additional Outcome
- Inflammatory markers including erythrocyte sedimentation rate, C-reactive protein, etc., body mass index, and incidence of adverse events.
- Study Method
- Intervention, Meta-analysis, Systematic review
- Keyword
- Gout; Humans; Phytotherapy
- Contact
- Sihan Peng [email protected]
- Organisational Affiliation
- Chengdu University of Traditional Chinese Medicine
- Funding Source
- This study was funded by Science and Technology key Program of Sichuan Province (2019YFS0196), Sichuan Provincial Administration of Traditional Chinese Medicine (2021MS095), Sichuan Collaborative Innovation Center for Old-age Care and Elderly Health（19ZL02）, and the Science and Technology Development Fund of Hospital of Chengdu University of Traditional Chinses Medicine (21HL04).
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2021-08-03
- Registration Date
- 2021-09-03
- Anticipated Start Date
- 2021-08-03
- Anticipated Completion Date
- 2023-06-30
- Title Cn
- 当归拈痛汤治疗痛风患者的有效性与安全性：系统评价与Meta分析
- Title En
- Efficacy and safety of Danggui niantong decoction in patients with gout: A systematic review and meta-analysis.
- Bilingual Status
- complete