Meta AnalysisID 5994
12种中药注射剂治疗急性脑梗死：系统评价与网状Meta分析方案
CRD42018109188
To compare the efficacy of twelve different Chinese medicine injections (CMIs) and to rank their benefits relative to each other for the treatment of acute cerebral infarction (ACI).
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Formula: 1Meta-analysis: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 5994
- Evidence Id
- 14552
- Core Evidence Id
- 14552
- Source Meta Analysis Id
- 5977
- Herb2 Meta Analysis Id
- HBMA005977
- Crd Id
- CRD42018109188
- Title
- Twelve kinds of Chinese medicine injections for acute cerebral infarction: protocol for a systematic review and network meta-analysis
- Review Question
- To compare the efficacy of twelve different Chinese medicine injections (CMIs) and to rank their benefits relative to each other for the treatment of acute cerebral infarction (ACI).
- Study Type Included
- Inclusion: randomized controlled trials (RCTs) related to CMIs in the treatment of ACI will be included for analysis, regardless of whether or not blinding has been used. Studies must report at least the primary outcome. No language or other restrictions will be imposed. Exclusion: RCTs from the same population (duplicate studies), those not reporting on effect estimates, those providing insufficient information with which to compute effect estimates, those which do not meet the curative effect valuation standard, and those reporting on outcome measures other than the outcome of interest will be excluded.
- Condition Being Studied
- Cerebral infarction refers to the formation of an area of necrosis in the cerebrum caused by an insufficiency of arterial or venous blood flow according to the definition of MeSH Terms of PubMed(https://www.ncbi.nlm.nih.gov/PubMed). Acute cerebral infarction is a clinical classification of cerebral infarction and the acute phase of ACI generally refers to 2 weeks after the onset of disease. As one of the major public health problems and the third costliest health condition in developed countries, ACI has a high disability, mortality and recurrence rate and usually leads to serious damage of central nervous system.There is a study shows that the brain loses 1.9 million neurons, 14 billion synapses, and 7.5 miles of myelinated nerve fibres every minute in a typical acute ischemic stroke. According to the top 10 causes of death provided by World Health Organisation(WHO), ischaemic heart disease and stroke are the world’s biggest killers, and have remained the leading causes of death globally in the last 15 years (http://www.who.int/news-room/fact-sheets/detail/the-top-10-causes-of-death). In China, cerebrovascular disease is the second large cause of death (http://www.docin.com/p-6587220.html). It is hoped that the findings of this study will facilitate the management and application of CMIs in the treatment of acute cerebral infarction (ACI).
- Participant
- Inclusion: patients with a definite diagnosis of acute cerebral infarction, regardless of the diagnostic criteria used. No limits will be imposed on age, gender, race or nationality. Exclusion: patients who are not in the acute phase of the disease, and patients who have a severe cognitive disorder, hemorrhagic tendency, or serious complications, such as atrial fibrillation, severe heart failure, severe liver and kidney diseases, or who are undergoing surgery or other physical therapies, will be excluded.
- Animal
- Human Disease Modelled
- Intervention
- Chinese medicine injections. Based on a preliminary analysis of the relevant literature on the treatment of acute cerebral infarction with CMIs, we have found that 12 kinds of CMIs are commonly used to treat acute cerebral infarction, all of which can dilate blood vessels, improve blood circulation and increase blood flow to the brain arteries. The 12 types of CMIs include: shuxuening injection, xiangdan injection, shuxuetong injection, kudiezi injection, xuesaitong injection, xueshuantong injection, dengzhanhuasu injection, danhong injection, dengzhanxixin injection, danshen injection, mailuoning injection and xingnaojing injection. No limitations on drug dosages or treatment courses will be imposed.
- Comparator Control
- Inclusion: conventional treatment, here defined as thrombolytic therapy, anticoagulant therapy and antiplatelet aggregation therapy. In addition, some symptomatic supportive treatments, such as control of blood pressure and adjustment of blood lipids will be included as well. Eligible comparisons will be as follows: 1) CMI a + conventional treatment versus CMI b + conventional treatment; 2) CMI + conventional treatment versus conventional treatment. No limitations on drug dosages or treatment courses will be imposed. Exclusion: considering that Western medicine is updated quickly, and that some drugs are withdrawn from the market, studies of CMIs combined with a specific less common Western medicines will be excluded.
- Main Outcome
- Mortality and the rate of cerebrovascular event including recurrence event.
- Outcome Measure
- Additional Outcome
- The secondary outcome of interest includes National Institutes of Health Stroke Scale (NIHSS).
- Study Method
- Intervention, Network meta-analysis, Systematic review
- Keyword
- Brain Ischemia; Cerebral Infarction; Humans; Injections; Medicine, Chinese Traditional; Stroke; Treatment Outcome
- Contact
- Dandan Yu [email protected]
- Organisational Affiliation
- China Academy of Chinese Medical Sciences
- Funding Source
- Natural Science Foundation of China
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2018-09-07
- Registration Date
- 2018-09-18
- Anticipated Start Date
- 2018-08-30
- Anticipated Completion Date
- 2019-05-31
- Title Cn
- 12种中药注射剂治疗急性脑梗死：系统评价与网状Meta分析方案
- Title En
- Twelve kinds of Chinese medicine injections for acute cerebral infarction: protocol for a systematic review and network meta-analysis
- Bilingual Status
- complete