Meta AnalysisID 5983
中国心绞痛单药治疗随机对照试验的网状Meta分析：方案
CRD42014007035
This study aims to compare, using network meta-analysis, the efficacies of Chinese patent medicines, shexiang baoxin pill (BXP), compound danshen dripping pill (DSP), compound danshen tablet (DST), suxiao jiuxin pill (JX
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Record Fields
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- Meta Analysis Id
- 5983
- Evidence Id
- 14541
- Core Evidence Id
- 14541
- Source Meta Analysis Id
- 5966
- Herb2 Meta Analysis Id
- HBMA005966
- Crd Id
- CRD42014007035
- Title
- Network meta-analysis of randomized controlled trials on the monotherapy of angina pectoris in China: a protocol
- Review Question
- This study aims to compare, using network meta-analysis, the efficacies of Chinese patent medicines, shexiang baoxin pill (BXP), compound danshen dripping pill (DSP), compound danshen tablet (DST), suxiao jiuxin pill (JXP), naoxintong capsule (NXT), tongxinluo capsule (TXL), di’ao xinxuekang capsule (XXK), and conventional drugs, atenolol (ATEN), isosorbide dinitrate (ISDN), and nifedipine (NIFE), in treating angina pectoris.
- Study Type Included
- Randomized controlled trials (RCTs) will be included. Observational cohort and case-control studies, case reports, experimental studies and reviews will be excluded.
- Condition Being Studied
- Coronary heart disease (CHD) angina pectoris is characterized by ischemia of the heart muscles and imbalance of coronary circulation. The symptoms of angina include chest pain, discomfort, and tightness in the neck, shoulders, jaw, or arms, particularly under physical or emotional stress. Patients suffering from angina are usually diagnosed by clinical examinations of symptoms (SYM), electrocardiograms (ECG), and blood enzyme levels.
- Participant
- Inclusion: participants suffering from and required treatment for angina pectoris. Exclusion: participants suffering from complicated heart disease conditions.
- Animal
- Human Disease Modelled
- Intervention
- Participants were treated by one of the following nine drugs: shexiang baoxin pill (BXP), compound danshen dripping pill (DSP), compound danshen tablet (DST), suxiao jiuxin pill (JXP), naoxintong capsule (NXT), tongxinluo capsule (TXL), di’ao xinxuekang capsule (XXK), atenolol (ATEN), isosorbide dinitrate (ISD), and nifedipine (NIF).
- Comparator Control
- Participants were treated by one of the included nine drugs other than the drug of interest.
- Main Outcome
- The first outcome was symptomatic (SYM) improvement that should achieve at least 50% (i.e. basic SYM improvement) or above 80% (i.e. significant SYM improvement) reduction in the frequency of feeling anginal chest pain.
- Outcome Measure
- Additional Outcome
- The second outcome was ECG improvement that should achieve at least 0.05 mV at ST segment (i.e. basic ECG improvement) or nearly normal ECG (i.e. significant ECG improvement).
- Study Method
- Intervention, Systematic review
- Keyword
- Angina Pectoris; China; Humans
- Contact
- Yongliang Jia [email protected]
- Organisational Affiliation
- Funding Source
- The study was part of the “Open systematic reviewing of clinical trials” project (PI: Siu-wai Leung) supported by a research grant (MYRG190 -Y3-L3-ICMS11-LSW) received from the University of Macau.
- Other Selection Criteria
- Final Publication
- Yongliang Jia, Siu-wai Leung. Are Chinese herbal drugs effective in treating angina pectoris? A frequentist network meta-analysis. The Lancet-CAMS Health Summit 2017. Beijing, China. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)33210-5/fulltext
- Same Topic Review
- The PRISMA-compliant systematic reviews with traditional pairwise meta-analysis indicate that some Chinese patent medicines such as DSP, TXL, and XXK are more efficacious than ISDN in treating angina. 1. Jia Y, Huang F, Zhang S, Leung S (2012) Is danshen (Salvia miltiorrhiza) dripping pill more e?ective than isosorbide dinitrate in treating angina pectoris? A systematic review of randomized controlled trials. Int J Cardiol 157: 330-340. 2. Jia Y, Bao F, Huang F, Leung S (2011) Is tongxinluo more effective than isosorbide dinitrate in treating angina pectoris? A systematic review and meta-analysis of randomized controlled trials. J Alternat Complement Med 17 (12): 1109-1117. 3. Jia Y, Chen C, Ng C, Leung S (2011) Meta-analysis of randomized controlled trials on the efficacy of di’ao xinxuekang capsule and isosorbide dinitrate in treating angina pectoris. Evid Based Complement Alternat Med 2012:904147. doi 10.1155/2012/904147.
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Completed not published
- First Submission Date
- 2018-12-10
- Registration Date
- 2014-01-13
- Anticipated Start Date
- 2012-01-12
- Anticipated Completion Date
- 2017-02-28
- Title Cn
- 中国心绞痛单药治疗随机对照试验的网状Meta分析：方案
- Title En
- Network meta-analysis of randomized controlled trials on the monotherapy of angina pectoris in China: a protocol
- Bilingual Status
- complete