Meta AnalysisID 5966
达立通颗粒联合质子泵抑制剂对比单用质子泵抑制剂治疗胃食管反流病的疗效与安全性：一项Meta分析
CRD42021285154
the mata-analysis evaluated whether the combination therapy PPI plus Dalitong Granule could improve the treatment effects and safety compared with PPI monotherapy in GERD patients, to provide an evidence-based reference
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Record Fields
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- Meta Analysis Id
- 5966
- Evidence Id
- 14524
- Core Evidence Id
- 14524
- Source Meta Analysis Id
- 5949
- Herb2 Meta Analysis Id
- HBMA005949
- Crd Id
- CRD42021285154
- Title
- Efficacy and Safety of Dalitong Granule in combination with Proton Pump Inhibitors versus Proton Pump Inhibitors alone in the treatment of gastroesophageal reflux disease:a meta-analysis
- Review Question
- the mata-analysis evaluated whether the combination therapy PPI plus Dalitong Granule could improve the treatment effects and safety compared with PPI monotherapy in GERD patients, to provide an evidence-based reference for clinical practice.
- Study Type Included
- Randomized controlled trials will be included.
- Condition Being Studied
- Gastroesophageal reflux disease (GERD) is among the most common conditions seen in ambulatory clinics and its disease burden continues to rise, with most recent studies reporting an 18 to 28% prevalence of GERD among North Americans.Although proton pump inhibitor (PPI) therapy is the mainstay pharmacologic management for GERD, accounting for approximately 30% patients do not respond to PPI.Relevant studies show that traditional Chinese medicine--dalitong granule plus PPI could reduce symptoms and improve treaty effects.
- Participant
- Inclusion criteria:people with gastroesophageal reflux disease(as diagnosed by a clinical , or using any recognized diagnostic criterias) Exclusion criteria:GERD patients with other digestive system diseases and/or systemic diseases.
- Animal
- Human Disease Modelled
- Intervention
- The experimental group was patients treated with Dalitong granule combined with PPI.The dosage, course of treatment and route of administration of drugs in the experimental group and the control group were not limited
- Comparator Control
- The control group was patients treated with PPI alone.The dosage, course of treatment and route of administration of drugs in the control group were not limited.
- Main Outcome
- Clinical symptoms improvement rate and endoscopic performance Measures of effect RR
- Outcome Measure
- Additional Outcome
- Adverse reactions Measures of effect RR
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Gastroesophageal Reflux; Humans; Proton Pump Inhibitors; Treatment Outcome
- Contact
- 段志军 [email protected]
- Organisational Affiliation
- 大连医科大学附属第一医院
- Funding Source
- 大连医科大学中西医结合学院
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2021-10-14
- Registration Date
- 2021-11-14
- Anticipated Start Date
- 2021-10-14
- Anticipated Completion Date
- 2021-11-27
- Title Cn
- 达立通颗粒联合质子泵抑制剂对比单用质子泵抑制剂治疗胃食管反流病的疗效与安全性：一项Meta分析
- Title En
- Efficacy and Safety of Dalitong Granule in combination with Proton Pump Inhibitors versus Proton Pump Inhibitors alone in the treatment of gastroesophageal reflux disease:a meta-analysis
- Bilingual Status
- complete