Meta AnalysisID 5824
中药注射液治疗哮喘急性发作：系统评价和网状Meta分析计划书
CRD42020151697
This study aims to assess and compare the efficacy and safety across and within Chinese medicine injections in patients with asthma exacerbations using data from randomised controlled trials (RCTs). Main efficacy and sa
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Formula: 1Meta-analysis: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 5824
- Evidence Id
- 14382
- Core Evidence Id
- 14382
- Source Meta Analysis Id
- 5805
- Herb2 Meta Analysis Id
- HBMA005805
- Crd Id
- CRD42020151697
- Title
- Chinese medicine injections for asthma exacerbations: protocol for a systematic review and network meta-analysis
- Review Question
- This study aims to assess and compare the efficacy and safety across and within Chinese medicine injections in patients with asthma exacerbations using data from randomised controlled trials (RCTs). Main efficacy and safety indexes include number of severe exacerbations during the invention or in a follow-up, changes in pre-bronchodilator forced expiratory volume in one second (FEV1) or FEV1% of predicted value from baseline, total effective rate and adverse effects.
- Study Type Included
- Strict inclusion/exclusion criteria have been defined for this study to limit heterogeneity and enhance clinical applicability. Only RCTs related to CMIs in the treatment of asthma exacerbations will be included for analysis. Duplicate studies with insufficient information to compute effect estimates will be excluded. No language or other restrictions will be applied.
- Condition Being Studied
- Asthma is a highly prevalent chronic inflammatory airway disease characterized by airway hyper responsiveness (AHR). The main medicines used in clinical practice include glucocorticoids, theophylline, anticholinergic and other anti-inflammatory drugs and antihistamines. Glucocorticoids have been identified as the most effective anti-inflammatory drugs. Among patients with persistent asthma that remains suboptimally controlled with the use of inhaled corticosteroids, asthma remains uncontrolled in a substantial number of patients who are at an increased risk of severe exacerbations and have reduced lung function. US guidelines suggest a stepwise approach to modifying therapy. Chinese medicine injections (CMIs) are recently found to play an important role in relieving cough and asthma and to have anti-allergy, anti-inflammatory, stress response, and immunoregulatory functions. CMIs are widely applied for adult asthma. Many clinical and experimental studies have shown that they may improve the clinical efficacy and lung function of patients with asthma exacerbations. This systematic review aims to assess the effectiveness and safety of CMIs for the treatment of asthma exacerbations, in order to provide evidence for the clinical practice of Chinese medicine.
- Participant
- RCTs with a definite diagnosis of asthma exacerbations (adults over 18 years old) will be taken into consideration. Most studies published in China will have adopted the standards revised by the Chinese expert consensus on asthma exacerbation in 2018. No age, sex or race restrictions imposed.
- Animal
- Human Disease Modelled
- Intervention
- Chinese medicine injections (CMIs) which were most commonly used to treat asthma exacerbations include Xuebijing injection, Tanreqing injection, Yuxingcao injection, Qingkailing injection, Reduning injection, Chuankezhi injection, Xixinnao injection, Xiyanping injection, Shenfu injection, Huangqi injection, Shengmai injection, Shenmai injection, Danshenchuanxiongqin injection. All of these 13 kinds of CMIs can improve clinical symptoms. No limitations on drug dosages or treatment courses will be imposed.
- Comparator Control
- To facilitate data analysis, conventional treatment has been defined as oxygen absorption, antispasmodic, antiasthmatic, anti-infective, anti-inflammatory and nutritional support. Eligible comparisons are as follows: a. CMIa + conventional treatment versus CMIb + conventional treatment; b. CMI + conventional treatment versus conventional treatment. Exclusion: considering that Western medicine is updated quickly, and that some drugs are withdrawn from the market, studies of CMIs combined with a specific less common Western medicine will be excluded.
- Main Outcome
- (1) Number of severe exacerbations during the invention or in a follow-up. (2) Changes in pre-bronchodilator forced expiratory volume in one second (FEV1) or FEV1% of predicted value from baseline. Measures of effect To be calculated at the end of the test and follow-up the exacerbations.
- Outcome Measure
- Additional Outcome
- (1) Total effective rate; (2) Adverse effects. Measures of effect To be calculated at the end of the test.
- Study Method
- Intervention, Meta-analysis, Network meta-analysis, Systematic review
- Keyword
- Asthma; Humans; Injections; Network Meta-Analysis
- Contact
- Haidu Hong [email protected]
- Organisational Affiliation
- Guangzhou University of Chinese Medicine http://www.gzucm.edu.cn/
- Funding Source
- This work is supported by the Science and technology program of Guangzhou, China (201803010053), the Traditional Chinese Medicine Administration of Guangdong Province, China (20174007), the Inheritance Workshop of Guangdong Province famous TCM doctor Xiaohong Liu, China (201805)
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- Chinese-Simplified, Chinese-Trad, English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2019-09-21
- Registration Date
- 2020-03-10
- Anticipated Start Date
- 2019-09-20
- Anticipated Completion Date
- 2019-12-31
- Title Cn
- 中药注射液治疗哮喘急性发作：系统评价和网状Meta分析计划书
- Title En
- Chinese medicine injections for asthma exacerbations: protocol for a systematic review and network meta-analysis
- Bilingual Status
- complete