Meta AnalysisID 5818
13种中药注射液治疗慢性阻塞性肺疾病急性加重：系统评价和网状Meta分析计划书
CRD42019132955
This study aims to assess and compare the efficacy across and within 13 kinds of CMIs, main efficacy index: forced expiratory volume in 1 second (FEV1), in patients with AECOPD using data from randomised controlled trial
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Record Fields
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- Meta Analysis Id
- 5818
- Evidence Id
- 14376
- Core Evidence Id
- 14376
- Source Meta Analysis Id
- 5799
- Herb2 Meta Analysis Id
- HBMA005799
- Crd Id
- CRD42019132955
- Title
- Thirteen kinds of chinese medicine injections for acute exacerbation of chronic obstructive pulmonary disease: protocol for a systematic review and network meta-analysis
- Review Question
- This study aims to assess and compare the efficacy across and within 13 kinds of CMIs, main efficacy index: forced expiratory volume in 1 second (FEV1), in patients with AECOPD using data from randomised controlled trials (RCTs).
- Study Type Included
- Strict inclusion/exclusion criteria have been defined for this study to limit heterogeneity and enhance clinical applicability. Only RCTs related to CMIs in the treatment of AECOPD will be included for analysis.Duplicate studies with insufficient information to compute effect estimates will be excluded. No language or other restrictions will be applied.
- Condition Being Studied
- Acute exacerbation of chronic obstructive pulmonary disease(AECOPD)
- Participant
- RCTs with a definite diagnosis of AECOPD will be taken into consideration. Most studies published in China will have adopted the standards revised by the Chinese expert consensus on acute exacerbation of chronic obstructive pulmonary disease in 2017.
- Animal
- Human Disease Modelled
- Intervention
- 13 kinds of Chinese medicine injections（CMIs） which were most commonly used to treat AECOPD：Xuebijing injection, Tanreqing injection, Yuxingcao injection, Qingkailing injection，Reduning injection，Chuankezhi injection，Xixinnao injection，Xiyanping injection，Shenfu injection, Huangqi injection, Shengmai injection, Shenmai injection, Danshenchuanxiongqin injection. All of these 13 kinds of CMIs can improve clinical symptoms. No limitations on drug dosages or treatment courses will be imposed.
- Comparator Control
- To facilitate data analysis, conventional treatment has been defined as Oxygen absorption, antispasmodic, antiasthmatic, anti-infective, anti-inflammatory and nutritional support. Eligible comparisons are as follows: a. CMIa+conventional treatment versus CMI b+conventional treatment; b. CMI+conventional treatment versus conventional treatment. Exclusion: considering that Western medicine is updated quickly, and that some drugs are withdrawn from the market, studies of CMIs combined with a specific less common Western medicine will be excluded.
- Main Outcome
- Pulmonary function is the gold standard for the diagnosis of COPD, and it is also an important part of disease prognosis and treatment evaluation. FEV1 in lung function is still the most important lung function index in current clinical examination, and it is the diagnosis of chronic obstructive pulmonary disease and airflow limitation. The gold standard for severity assessment is also one of the most important indicators for clinical efficacy assessment. Therefore, this study used FEV1 as the main efficacy index. Measures of effect The pooled odds ratios with 95% confidence interval are calculated for dichotomous data Weighted Mean Difference（WMD） with 95% confidence interval are calculated for continuous data(Forced expiratory volume in one second)
- Outcome Measure
- Additional Outcome
- The efficacy evaluation index system for AECOPD based on expert questionnaire includes indicators of medical attention, indicators of patient attention, laboratory parameters.The concentrated evaluation index of expert advices included arterial oxygen pressure, asthmatic, artery CO2 pressure, etc. According to the evaluation index of weights, the indexes included economic indicators, BODE index, SAFE index, the smallest changes in the value of clinical significance, pulmonary function and dyspnea questionnaire, etc. Measures of effect Not applicable
- Study Method
- Intervention, Meta-analysis, Network meta-analysis, Systematic review
- Keyword
- Humans; Injections; Medicine, East Asian Traditional; Network Meta-Analysis; Pulmonary Disease, Chronic Obstructive
- Contact
- Wenjiang Zheng [email protected]
- Organisational Affiliation
- The First Clinical College of Guangzhou University of Chinese Medicine www.gztcm.com.cn/gztcm/zzjy.html
- Funding Source
- This work is supported by a grant from the Traditional Chinese Medicine Administration of Guangdong Province, China (20174007), and supported by Inheritance Workshop of Guangdong Province famous TCM doctor Xiaohong Liu, China(201805).
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2019-04-24
- Registration Date
- 2019-06-03
- Anticipated Start Date
- 2019-04-30
- Anticipated Completion Date
- 2019-09-30
- Title Cn
- 13种中药注射液治疗慢性阻塞性肺疾病急性加重：系统评价和网状Meta分析计划书
- Title En
- Thirteen kinds of chinese medicine injections for acute exacerbation of chronic obstructive pulmonary disease: protocol for a systematic review and network meta-analysis
- Bilingual Status
- complete