Meta AnalysisID 5744
鼻渊通窍颗粒治疗儿童慢性鼻窦炎的系统评价和Meta分析
CRD42021288147
Can Biyuan Tongqiao Keli be applied in the Treatment of Pediatric Chronic Rhinosinusitis? (1) Is it efficacy enough? (2) Is that safe for children?
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Record Fields
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- Meta Analysis Id
- 5744
- Evidence Id
- 14302
- Core Evidence Id
- 14302
- Source Meta Analysis Id
- 5724
- Herb2 Meta Analysis Id
- HBMA005724
- Crd Id
- CRD42021288147
- Title
- The combination of Biyuan Tongqiao Keli in the Treatment of Pediatric Chronic Rhinosinusitis: Meta-analysis and Systematic Review
- Review Question
- Can Biyuan Tongqiao Keli be applied in the Treatment of Pediatric Chronic Rhinosinusitis? (1) Is it efficacy enough? (2) Is that safe for children?
- Study Type Included
- We will include randomised controlled trials to assess the beneficial effects and the safety effects of the treatments.
- Condition Being Studied
- pediatric chronic rhinosinusitis
- Participant
- Children who meet the diagnostic criteria for pediatric chronic rhinosinusitis, that is, clinical symptoms (nasal congestion, sticky or purulent nasal discharge must have one symptom, head and face pain, hyposmia or loss of one or more), nose Endoscopy (indicating viscous or mucopurulent secretions from the middle nasal passage, olfactory cleft, nasal mucosal congestion, edema, or polyps) mainly, refer to the CT scan of the sinuses for indications (showing oral and nasal complex and/ or sinus mucosal inflammatory lesions), which is in line with the Children's Rhinosinusitis Diagnosis and Treatment Recommendations (2012, Kunming) formulated by the Pediatrics Group and Rhinology Group of the Otorhinolaryngology Head and Neck Surgery Branch of the Chinese Medical Association or the Chinese Medical Association Otorhinolaryngology The “Guidelines for the Diagnosis and Treatment of Chronic Rhinosinusitis (Nanchang, 2008)” formulated by the Rhinology Group of the Branch of Throat, Head and Neck Surgery Description of the diagnosis of chronic sinusitis in children in Efficacy Evaluation Criteria or Otorhinolaryngology, Otorhinolaryngology Diagnosis, Otorhinolaryngology Head and Neck Surgery in children. The child is under 18 years of age, gender is not limited, and the course of the disease is not limited , The course of treatment is within 12 weeks.
- Animal
- Human Disease Modelled
- Intervention
- Combined with the treatment of Biyuan Tongqiao Granules on the basis of the control group. The control group include: conventional treatment, in line with clinical diagnosis and treatment guidelines recommended medication, specifically including nasal saline irrigation, nasal or oral glucocorticoids, oral macrolides, antibiotics, antihistamines, Anti-leukotriene drugs, mucolysis promoting agents, decongestants.
- Comparator Control
- Conventional treatment, in line with clinical diagnosis and treatment guidelines recommended medication, specifically including nasal saline irrigation, nasal or oral glucocorticoids, oral macrolides, antibiotics, antihistamines, Anti-leukotriene drugs, mucolysis promoting agents, decongestants.
- Main Outcome
- Main outcome indicators include: Lund-Kennedy score according to nasal endoscopic mucosal morphology examination, Lund-Mackay score according to sinus CT examination Measures of effect The Lund-Kennedy score, can be measured by nasal endoscopic mucosal morphology examination, and the Lund-Mackay score can be measured by sinus CT examination.
- Outcome Measure
- Additional Outcome
- Additional outcomes include VAS score, nasal mucociliary transport rate (MTR), nasal mucociliary clearance rate (MCC), serum interleukin-2 (IL-2), nasal congestion symptom score, runny (pus) symptom score , Olfactory dysfunction symptom score, and the efficacy rate. The incidence of adverse reactions are also taken into consideration as the safety indicator.
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Child; Drugs, Chinese Herbal; Humans
- Contact
- Hongzheng Li [email protected]
- Organisational Affiliation
- Xiyuan Hospital China Academy of Chinese Medicine
- Funding Source
- National Natural Science Foundation of China Grant number(s) <span style=font-size: 14px>State the funder, grant or award number and the date of award</span> 81774146
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2021-10-29
- Registration Date
- 2021-11-29
- Anticipated Start Date
- 2021-11-08
- Anticipated Completion Date
- 2021-12-06
- Title Cn
- 鼻渊通窍颗粒治疗儿童慢性鼻窦炎的系统评价和Meta分析
- Title En
- The combination of Biyuan Tongqiao Keli in the Treatment of Pediatric Chronic Rhinosinusitis: Meta-analysis and Systematic Review
- Bilingual Status
- complete