Meta AnalysisID 566

西番莲属植物的传统用途、化学成分、抗氧化潜力及安全性：一项系统评价

CRD42022318952

Is the exposure of animals to the internal use of extracts, phases and enriched fractions derived from species of the Passiflora spp. is safe? Context and rationale The Passifloraceae family has 30 accepted genera and mo

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Meta Analysis Id: 566
Evidence Id: 9124
Core Evidence Id: 9124
Source Meta Analysis Id: 545
Herb2 Meta Analysis Id: HBMA000545
Crd Id: CRD42022318952
Title: Traditional uses, chemical composition, antioxidant potential and security of Passiflora species: A systematic review
Review Question: Is the exposure of animals to the internal use of extracts, phases and enriched fractions derived from species of the Passiflora spp. is safe? Context and rationale The Passifloraceae family has 30 accepted genera and more than 500 species are known to science. Species of the genus Passiflora, the largest of the family, are distributed in various parts of the world and one of the most striking botanical characteristics of the genus are the exotic flowers that its bushes provide, used for ornamental purposes, in addition to the pulp of the fruits that provide pleasant juices. In folk medicine, preparations obtained from the leaves and roots are used as anxiolytic, sedative, diuretic and analgesic agents. The phytochemical study showed the presence of several secondary metabolites of interest, such as flavonoids, alkaloids, phenols, cyanogenic compounds and saponins, responsible for their pharmacological activities, such as the antioxidant, which stands out for protecting cells from the harmful effects of radicals. from the body itself, helping to prevent various diseases such as cancer, of the cardiovascular system, in addition to helping the immune system. According to the main regulatory agency for medicines in Brazil, ANVISA, there are currently 57 herbal medicines registered whose active ingredient is Passiflora incarnata. It is worth mentioning that species of the genus such as P. alata, edulis and P. incarnata itself are included in the RENISUS (National List of Medicinal Plants of interest to SUS) so that further research can be carried out to investigate their potential for the development of products, with emphasis on native species. Despite being of natural origin, plant products are not free from risks to human health and confirming the safety of plant extracts used in folk medicine or still unknown is an important step in pre-clinical studies to continue studies for the development of formulations, aiming to guarantee consumer safety through animal tests, provided that, respecting the bioethical protocols for these tests. Based on this, the objective of this work was to compile data with methodological quality that provide a better knowledge about the safety of using species of the genus Passiflora in animal studies, also including information on traditional uses, chemical composition and antioxidant activity so that it can serve as a reference source for researchers and health professionals.
Study Type Included: Inclusion criteria: Original articles that describe: - Preclinical studies in animals with a separate control group; - Cross design, - Study designs randomized and non-randomised. Exclusion criteria: - It is not a model of oral or intraperitoneal intoxication; - Before-after studies without a control group; - Studies observational - Case study
Condition Being Studied
Participant
Animal: Inclusion criteria: - animals of all sexes, ages and all species/strains - experimental models of orality and intraperitoneal intoxication in animals treated with vehicle/placebo or control with healthy animals. Exclusion criteria: - Clinical trials in humans or animals with comorbidity - In vitro, ex vivo and in silico study - Studies without before-after control groups
Human Disease Modelled: Cancer is a chronic disease that acts by proliferating defective cells that cannot be destroyed by the body and spread throughout the body, and can be quite aggressive, generating metastases. Studies in the area correlate the incidence of cancers due to oxidative processes linked to bad habits such as a sedentary lifestyle, the environment and drugs such as alcohol and tobacco. Most of the drugs available for the treatment of this cellular disorder are synthetic derivatives of natural products that can have severe side effects in their carriers. Therefore, it is necessary to investigate new promising natural agents for the treatment of cancer, based on their antioxidant effect and that offer a low risk of toxicity during treatment.
Intervention: Inclusion criteria: - treatment with extracts, phases or purified fractions of passiflora, administered at any time and dosing frequency Exclusion criteria: -Oral and intraperitoneal animal models treated with synthetic substances or preparations of mixtures of other plants with passiflora species or passionflower extracts combined with drugs
Comparator Control: Inclusion criteria: Animal models of oral and intraperitoneal intoxication treated with either vehicle/placebo, or health animal control Exclusion criteria: Experiments without comparison group; Animal models of oral and intraperitoneal intoxication treated with any other drug.
Main Outcome
Outcome Measure: Inclusion criteria: - The primary outcome were: LD50; LD100; survival and signs of intoxication or adverse effects (eg.general behavior). Secondary outcomes: will be evaluated from the in vivo models: the body weight of the animals; preliminary organ results (weight measurement and histopathological analysis. For blood: red blood cell count, hemoglobin, hematocrit, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, platelet count, white blood cell count, differential count of leukocytes; For biochemical analysis: alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase and total proteins. For hepatic activity: ureic nitrogen and ureic acid. For renal function, creatinine. For pancreatic function, amylase. The results of locomotion activity will also be considered and muscle tone, given by the number of squares covered by the animals, number of creation and muscular strength of these. Exclusion criteria: no outcomes of interest
Additional Outcome
Study Method
Keyword: Animals; Antioxidants; Passiflora
Contact: Rafael Silva [email protected]
Organisational Affiliation: None.
Funding Source: None. Grant number(s) None.
Other Selection Criteria: - Review articles - Case reports - Editorials - Letters from the editor - Works presented at scientific events - Comments - Dissertations and Theses.- Abstracts of works published in scientific events (annals, conferences, etc.) - Letters to the editor - Works in languages other than English, Portuguese and Spanish
Final Publication
Same Topic Review: Not applied.
Published Protocol
Review Type: Pre-clinical animal intervention review
Language: English, Portuguese-Brazil
Country: Argentina, Brazil
Review Stage: Review Ongoing
First Submission Date: 2022-04-07
Registration Date: 2022-05-03
Anticipated Start Date: 2022-03-13
Anticipated Completion Date: 2023-03-13
Title Cn: 西番莲属植物的传统用途、化学成分、抗氧化潜力及安全性：一项系统评价
Title En: Traditional uses, chemical composition, antioxidant potential and security of Passiflora species: A systematic review
Bilingual Status: complete