Meta AnalysisID 5649
安宫牛黄丸辅助治疗急性卒中的系统评价与Meta分析
CRD42022319660
The aim of this meta-analysis is to systematically evaluate the efficacy and safety of angong Niuhuang pill in the treatment of acute stroke
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Record Fields
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- Meta Analysis Id
- 5649
- Evidence Id
- 14207
- Core Evidence Id
- 14207
- Source Meta Analysis Id
- 5631
- Herb2 Meta Analysis Id
- HBMA005631
- Crd Id
- CRD42022319660
- Title
- A systematic review and meta-analysis of Angong Niuhuang Pill for adjuvant treatment of acute stroke
- Review Question
- The aim of this meta-analysis is to systematically evaluate the efficacy and safety of angong Niuhuang pill in the treatment of acute stroke
- Study Type Included
- Randomized controlled trial (RCT), Chinese and English only.
- Condition Being Studied
- Stroke disease, is abrupt faint servant, unconscious, hemiplegia, mouth eye askew, language disadvantage is the main disease syndrome. Acute period is within 2 weeks after onset, the viscera can be extended to 1 month. Stroke is the second cause of death among people over 60 years old worldwide and has become the first cause of death for elderly patients in China. High morbidity, high mortality and high disability rate are the important characteristics of this disease. Western medicine mainly focuses on routine treatment, including airway patency, intracranial pressure reduction and brain protection. Angong Niuhuang pill has the effect of clearing heat and detoxifying, calming shock and opening the body. Studies have shown that the drug can inhibit inflammation, reduce brain edema, reduce apoptosis, and have a protective effect on brain tissue damage.
- Participant
- Inclusion criteria: Patients diagnosed as hemorrhagic stroke were confirmed by CT/MRI according to the diagnostic criteria of hemorrhagic stroke published in the 2019 Chinese Guidelines for the Diagnosis and Treatment of Cerebral Hemorrhage or other authoritative institutions; Patients diagnosed with acute stage of ischemic stroke, cerebral infarction and cerebral thrombosis confirmed by CT/MRI according to The 2018 Guidelines for the Diagnosis and Treatment of Acute Ischemic Stroke in China, regardless of age or gender. Exclusion criteria: ① The diagnostic criteria of the design scheme are not clear; ② Cerebrovascular diseases caused by trauma, intracranial vascular malformation and cerebral arteritis; ③ Repeated publication; ④ Animal experiments, conference documents, expert experience, case reports and reviews.
- Animal
- Human Disease Modelled
- Intervention
- The experimental group was supplemented with angong Niuhuang pill on the basis of conventional treatment.The dosage is unlimited and the duration of medication is ≥ 3 days. Intervention measures of the two groups were consistent except for Angong Niuhuang pill.
- Comparator Control
- The control group received routine treatment as required by the guidelines.
- Main Outcome
- ① Efficiency. ② National Institutes of Health Stroke Scale (NIHSS) score; ③ Glasgow Coma Scale (GCS) score;
- Outcome Measure
- Additional Outcome
- ① Scores of mini-Mental State Examination (MMSE); ② Activity of Daily Living (ADL) score; ③ Barthel index score; ④Serum brain natriuretic peptide (BNP); ⑤The incidence of adverse reactions.
- Study Method
- Intervention, Meta-analysis, Systematic review
- Keyword
- Angong Niuhuang Pill; Drug Combinations; Drugs, Chinese Herbal; Humans; Stroke
- Contact
- Xiangran Meng [email protected]
- Organisational Affiliation
- Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medicine Sciences
- Funding Source
- No funding source/sponsor.
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-03-21
- Registration Date
- 2022-04-20
- Anticipated Start Date
- 2022-03-21
- Anticipated Completion Date
- 2022-04-28
- Title Cn
- 安宫牛黄丸辅助治疗急性卒中的系统评价与Meta分析
- Title En
- A systematic review and meta-analysis of Angong Niuhuang Pill for adjuvant treatment of acute stroke
- Bilingual Status
- complete