Meta AnalysisID 5638
九种中药注射剂联合化疗治疗晚期食管癌的有效性与安全性：网状Meta分析
CRD42022355746
The incidence of esophageal cancer is increasing year by year, and it is mostly found in the middle and late stages, and the survival rate is extremely low, which seriously threatens human health. While chemotherapeutic
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Record Fields
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- Meta Analysis Id
- 5638
- Evidence Id
- 14196
- Core Evidence Id
- 14196
- Source Meta Analysis Id
- 5621
- Herb2 Meta Analysis Id
- HBMA005621
- Crd Id
- CRD42022355746
- Title
- Effectiveness and safety of 9 traditional Chinese medicine injections combined with chemotherapy in the treatment of advanced esophageal cancer:a network meta-analysis
- Review Question
- The incidence of esophageal cancer is increasing year by year, and it is mostly found in the middle and late stages, and the survival rate is extremely low, which seriously threatens human health. While chemotherapeutic drugs are used to treat diseases, they can also bring great side effects and affect the quality of life of patients. Traditional Chinese medicine injections can help chemotherapy patients reduce adverse reactions and improve clinical efficacy. However, there are various types of TCM injections. Which is the best intervention? There is no exact statement. Therefore, there is an urgent need to accurately understand the efficacy and safety of various traditional Chinese medicine injections in the treatment of esophageal cancer, and to find the best intervention measures.This systematic review is aimed at patients with advanced esophageal cancer; the intervention measures are nine traditional Chinese medicine injections combined with conventional chemotherapy, and the control measure is conventional chemotherapy; the main outcomes are efficacy, improvement rate of quality of life, immune function cell level, tumor markers The drug level, the incidence of adverse reactions, etc.; the research method is a randomized controlled trial.
- Study Type Included
- randomised controlled trial
- Condition Being Studied
- The incidence of esophageal cancer is increasing year by year, and it is mostly found in the middle and late stages, and the survival rate is extremely low, which seriously threatens human health.
- Participant
- Advanced esophageal cancer
- Animal
- Human Disease Modelled
- Intervention
- Aidi Injection combined with conventional chemotherapy or Shenfu Injection combined with conventional chemotherapy or Shenmai Injection combined with conventional chemotherapy or Shenqi Fuzheng Injection combined with conventional chemotherapy or Fufang Kushen Injection combined with conventional chemotherapy or Cinobufasu Injection combined with conventional chemotherapy or Kanglaite Injection combined with conventional chemotherapy or Xiaoaiping Injection combined with conventional chemotherapy or Brucae Injection combined with conventional chemotherapy
- Comparator Control
- conventional chemotherapy（DF scheme or ND scheme or TP scheme etc. ）
- Main Outcome
- the main outcomes are efficacy, the short-term efficacy was classified into four grades: complete remission (CR), partial remission (PR), stable (NC) and progressive (PD) according to the solid tumor evaluation criteria developed by UICC. CR + PR is valid (RR). Complete remission (CR) is defined as the disappearance of the main symptoms such as chest pain and dysphagia; partial remission (PR) is defined as the disappearance of some symptoms or related symptoms are alleviated; there is no significant improvement in symptoms, which is stable (SD); This is called progress (PD). Measures of effect RR
- Outcome Measure
- Additional Outcome
- improvement rate of quality of life, immune function cell level, tumor markers The drug level, the incidence of adverse reactions, etc Measures of effect RR
- Study Method
- Systematic review
- Keyword
- Drugs, Chinese Herbal; Esophageal Neoplasms; Humans; Injections; Medicine, Chinese Traditional; Network Meta-Analysis
- Contact
- Yuqing Yang [email protected]
- Organisational Affiliation
- Henan University of Chinese Medicine
- Funding Source
- This work wil be supported by Henan Province Key Scientific Research Project of Higher Education Institutions, Henan Province Traditional Chinese Medicine Top Talent Training Project, and Henan Province Traditional Chinese Medicine Scientific Research Special Project. Grant number(s) <span style=font-size: 14px>State the funder, grant or award number and the date of award</span> 19A360015;2022ZY1049
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-08-25
- Registration Date
- 2022-09-05
- Anticipated Start Date
- 2022-07-31
- Anticipated Completion Date
- 2022-12-31
- Title Cn
- 九种中药注射剂联合化疗治疗晚期食管癌的有效性与安全性：网状Meta分析
- Title En
- Effectiveness and safety of 9 traditional Chinese medicine injections combined with chemotherapy in the treatment of advanced esophageal cancer:a network meta-analysis
- Bilingual Status
- complete