Meta AnalysisID 5637
艾迪注射液联合铂类化疗经胸腔灌注治疗恶性胸腔积液的临床疗效与安全性：随机对照试验的系统评价与Meta分析
CRD42022341809
Disscuss the clinical efficacy and safety of intrapleural infusion with Aidi Injection plus platinum drugs in the treatment of malignant pleural effusion compared to platinum drugs alone
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Formula: 1Meta-analysis: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 5637
- Evidence Id
- 14195
- Core Evidence Id
- 14195
- Source Meta Analysis Id
- 5620
- Herb2 Meta Analysis Id
- HBMA005620
- Crd Id
- CRD42022341809
- Title
- Clinical Efficacy and Safety of Aidi Injection combined with Platinum-Based Chemotherapy on Malignant Pleural Effusion via Thoracic Perfusion: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
- Review Question
- Disscuss the clinical efficacy and safety of intrapleural infusion with Aidi Injection plus platinum drugs in the treatment of malignant pleural effusion compared to platinum drugs alone
- Study Type Included
- Inclusion Criteria of the Study: 1) The study design is limited to RCTs comparing platinum drugs plus Aidi Injection (Treatment group) with platinum drugs alone (Control group) in the treatment of MPE 2) the subjects of MPE must be diagnosed pathologically and/or cytologically 3) the outcomes must be determined according to RECIST, and the QOL changes must be assessed by KPS Exclusion Criteria of the Study: 1) Animal experiments, reviews and other unrelated studies 2) patients also receiving treatment drugs outside the regimen 3) no detailed data on ORR, QOL and adverse reactions, or no indicators for them 4) lack of comparable control groups 5) single-arm study
- Condition Being Studied
- Aidi Injection; malignant pleural effusion; thoracic perfusion
- Participant
- Inclusion Criteria of the Study: 1) The study design is limited to RCTs comparing platinum drugs plus Aidi Injection (Treatment group) with platinum drugs alone (Control group) in the treatment of MPE 2) the subjects of MPE must be diagnosed pathologically and/or cytologically 3) the outcomes must be determined according to RECIST, and the QOL changes must be assessed by KPS Exclusion Criteria of the Study: 1) Animal experiments, reviews and other unrelated studies 2) patients also receiving treatment drugs outside the regimen 3) no detailed data on ORR, QOL and adverse reactions, or no indicators for them 4) lack of comparable control groups 5) single-arm study
- Animal
- Human Disease Modelled
- Intervention
- Intervention in the experimental group: Aidi Injection combined with platinum drugs via thoracic perfusion
- Comparator Control
- The control group: platinum drugs via thoracic perfusion alone
- Main Outcome
- The primary outcome was defined as Objective Remission Rate between platinum drugs plus Aidi Injection versus platinum drugs alone via intrapleural injection for Malignant Pleural Effusion. The secondary outcomes included quality of life and adverse drug reactions.
- Outcome Measure
- Additional Outcome
- Study Method
- Intervention, Meta-analysis, Systematic review
- Keyword
- Humans; Lung Neoplasms; Perfusion; Pleural Effusion, Malignant; Randomized Controlled Trials as Topic; Treatment Outcome
- Contact
- Yuanyuan Qin [email protected]
- Organisational Affiliation
- 1 Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine; 2 The First School of Clinical Medicine Nanjing University of Chinese Medicine; 3 Jiangsu Collaborative Innovation Center of Chinese Medicine Prevention and Treatment of Tumor Nanjing University of Chinese Medicine Nanjing
- Funding Source
- National Natural Science Foundation of China (No. 81774266); National Natural Science Foundation of China Youth Fund((No. 81804058); Traditional Chinese Medicine Inheritance and Innovation Baiwan Talent Project (Qihuang Project)(Department of Personnel and Education of National Administration of Traditional Chinese Medicine, No〔2018〕284)，State Administration of Traditional Chinese Medicine of the Sixth batch of national senior Chinese medicine experts academic experience inheritance work(Department of Personnel and Education of National Administration of Traditional Chinese Medicine, No〔2017〕29)
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-06-23
- Registration Date
- 2022-07-04
- Anticipated Start Date
- 2022-06-20
- Anticipated Completion Date
- 2022-12-20
- Title Cn
- 艾迪注射液联合铂类化疗经胸腔灌注治疗恶性胸腔积液的临床疗效与安全性：随机对照试验的系统评价与Meta分析
- Title En
- Clinical Efficacy and Safety of Aidi Injection combined with Platinum-Based Chemotherapy on Malignant Pleural Effusion via Thoracic Perfusion: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
- Bilingual Status
- complete