Meta AnalysisID 5516
维生素B6与结直肠癌风险的相关性：系统评价与Meta分析
CRD42022352776
Previous meta-analyses investigating the relationship between vitamin B6 and colorectal cancer incidence have included a relatively small number of original studies, and in recent years an increasing number of original s
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 5516
- Evidence Id
- 14074
- Core Evidence Id
- 14074
- Source Meta Analysis Id
- 5501
- Herb2 Meta Analysis Id
- HBMA005501
- Crd Id
- CRD42022352776
- Title
- Association between vitamin B6 and the risk of colorectal cancer: a systemic review and meta-analysis
- Review Question
- Previous meta-analyses investigating the relationship between vitamin B6 and colorectal cancer incidence have included a relatively small number of original studies, and in recent years an increasing number of original studies have been published that have reached the opposite conclusion. Therefore, we started a new meta-analysis to draw more accurate conclusions
- Study Type Included
- Case-control studies or cohort studies
- Condition Being Studied
- Colorectal cancer, currently the third most common cancer in the world, imposes a severe burden on the world's health system. Researchers around the world are currently looking for ways to prevent colorectal cancer. Vitamin B6 is a common vitamin in our life and exists in a variety of daily foods. Pyridoxine 5-phosphate (PLP) is the main active coenzyme form of vitamin B6 and is involved in nearly 100 enzymatic reactions. Therefore, low vitamin B6 levels may increase the risk of colorectal cancer through aberrations in DNA synthesis, repair, and methylation. Vitamin B6 may also inhibit colorectal cancer development by reducing cell proliferation, angiogenesis, oxidative stress, inflammation, and nitric oxide synthesis.
- Participant
- Studies were included in the meta analysis if they met the following criteria: (1) they were cohort studies or case-control studies; (2) the exposure of interest was intake of vitamin B6 or blood (plasma or serum) levels of PLP; (3) the outcome of interest was the incidence of colorectal, colon, or rectal cancer; and (4) relative risk (RR) or odds ratio (OR) estimates with 95 % confidence intervals (95 % CI) were reported.
- Animal
- Human Disease Modelled
- Intervention
- High vitamin B6 intake or high Pyridoxine 5-phosphate in blood
- Comparator Control
- Low vitamin B6 intake or low Pyridoxine 5-phosphate in blood.
- Main Outcome
- Incidence of colorectal cancer. Measures of effect Pooled relative risk (RR) and 95% confidence interval (CI) were generated through random-effects model.
- Outcome Measure
- Additional Outcome
- None.
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Colorectal Neoplasms; Humans; Risk Factors; Vitamin B 6
- Contact
- jianxiong lai [email protected]
- Organisational Affiliation
- The Third Hospital of Mianyang (Sichuan Mental Health Center)
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-08-11
- Registration Date
- 2022-08-22
- Anticipated Start Date
- 2022-08-11
- Anticipated Completion Date
- 2022-11-30
- Title Cn
- 维生素B6与结直肠癌风险的相关性：系统评价与Meta分析
- Title En
- Association between vitamin B6 and the risk of colorectal cancer: a systemic review and meta-analysis
- Bilingual Status
- complete