Meta AnalysisID 5498
补充维生素K对慢性肾脏病患者血管钙化的影响：随机对照试验的系统评价和Meta分析
CRD42022343857
Does vitamin K supplementation delay or even reverse vascular calcification in patients with chronic kidney diseases?
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 5498
- Evidence Id
- 14056
- Core Evidence Id
- 14056
- Source Meta Analysis Id
- 5483
- Herb2 Meta Analysis Id
- HBMA005483
- Crd Id
- CRD42022343857
- Title
- Effects of Vitamin K Supplementation on Vascular Calcification in Chronic Kidney Disease: A Systematic Review and Meta-analysis of Randomized Controlled Trials
- Review Question
- Does vitamin K supplementation delay or even reverse vascular calcification in patients with chronic kidney diseases?
- Study Type Included
- RCTs
- Condition Being Studied
- Vascular calcification in chronic kidney diseases.
- Participant
- Patients with chronic kidney diseases, including end stage renal disease.
- Animal
- Human Disease Modelled
- Intervention
- Vitamin K supplementation
- Comparator Control
- Intervention without vitamin K supplementation, including placebo or other matched drugs.
- Main Outcome
- Two categories of outcomes were considered as the effect outcomes for this me-ta-analysis. The first category was absolute and relative changes of biochemical measures known to be related to vascular calcification, including osteocalcin (OC) and dephosphorylated uncarboxylated matrix Gla protein (dp-ucMGP). The second category was absolute and relative changes of imaging measures of vascular calcification, in-cluding coronary artery Agaston score, aortic Agaston score, valve Agaston score, cor-onary artery calcification volume score, valve calcification volume score, and pulse wave velocity (PWV). Measures of effect Mean differences (MD) or standardized mean differences (SMD) with 95% CI of studied outcomes between experimental and control groups for effects outcomes.
- Outcome Measure
- Additional Outcome
- Safety outcome, including any adverse event and death. Measures of effect Risk ratios.
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Dietary Supplements; Humans; Randomized Controlled Trials as Topic; Renal Insufficiency, Chronic; Vascular Calcification; Vitamin K
- Contact
- Yunlin Feng [email protected]
- Organisational Affiliation
- Sichuan Provincial People's Hospital
- Funding Source
- This work was supported in part by the Clinical research grant of Sichuan Provincial People's Hospital (2020LY02).
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-07-02
- Registration Date
- 2022-07-13
- Anticipated Start Date
- 2022-07-01
- Anticipated Completion Date
- 2022-09-01
- Title Cn
- 补充维生素K对慢性肾脏病患者血管钙化的影响：随机对照试验的系统评价和Meta分析
- Title En
- Effects of Vitamin K Supplementation on Vascular Calcification in Chronic Kidney Disease: A Systematic Review and Meta-analysis of Randomized Controlled Trials
- Bilingual Status
- complete