Meta AnalysisID 5485
维生素K拮抗剂对比新型口服抗凝药治疗颈动脉夹层：交互式系统评价与Meta分析
CRD42022337739
P: patients with cervical artery dissection I: novel oral anticoagulants (NOAC) C: vitamin K antagonists (VKA) anticoagulants O: clinical and radiologic outcomes, rates of TIA/stroke and hemorrhage
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 5485
- Evidence Id
- 14043
- Core Evidence Id
- 14043
- Source Meta Analysis Id
- 5469
- Herb2 Meta Analysis Id
- HBMA005469
- Crd Id
- CRD42022337739
- Title
- Vitamin K Antagonist versus Novel Oral Anticoagulants for Management of Cervical Artery Dissection: Interactive Systematic Review and Meta-analysis
- Review Question
- P: patients with cervical artery dissection I: novel oral anticoagulants (NOAC) C: vitamin K antagonists (VKA) anticoagulants O: clinical and radiologic outcomes, rates of TIA/stroke and hemorrhage
- Study Type Included
- All types of clinical studies (randomized control trials, cohort studies) except for case reports.
- Condition Being Studied
- The use of vitamin K antagonist anticoagulants (VKA) and novel oral anticoagulants (NOAC) in the treatment of cervical artery dissection (CAD).
- Participant
- Patients with Cervical artery dissection
- Animal
- Human Disease Modelled
- Intervention
- vitamin K antagonist anticoagulants (VKA) and novel oral anticoagulants (NOAC)
- Comparator Control
- Treatment groups
- Main Outcome
- Outcomes of interest were stratified by applied medical treatment into two groups; patients receiving VKA and ones treated with NOAC. Clinical outcomes included good outcomes (mRS 0-2), poor outcomes (mRS 3-5), mortality rates, rates of TIA or stroke, intracranial bleeding, and minor and major bleeding. Radiographic outcomes included partial or total angiographic recanalization rates of the occluded dissected vessel and rates of angiographic worsening. Angiographic worsening was defined as a progressive occlusive or aneurysmal morphological changes in the dissected vessel. Measures of effect The cumulative incidence (event rate per patient at the end of the study) for each study was estimated and 95% CI. We used a random-effects model to pool incidence rates across studies because of the marked heterogeneity that we expected in the populations and interventions across various studies. The I² statistic was used to express the proportion of inconsistency not attributable to chance.
- Outcome Measure
- Additional Outcome
- Study Method
- Intervention, Meta-analysis, Systematic review
- Keyword
- Anticoagulants; Arteries; Humans; Vitamin K; Warfarin
- Contact
- Muhammed Amir Essibayi [email protected]
- Organisational Affiliation
- Department of Neurosurgery, Mayo Clinic, Rochester.
- Funding Source
- None Grant number(s) <span style=font-size: 14px>State the funder, grant or award number and the date of award</span> None
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- United States of America
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-06-06
- Registration Date
- 2022-06-17
- Anticipated Start Date
- 2022-02-01
- Anticipated Completion Date
- 2022-07-06
- Title Cn
- 维生素K拮抗剂对比新型口服抗凝药治疗颈动脉夹层：交互式系统评价与Meta分析
- Title En
- Vitamin K Antagonist versus Novel Oral Anticoagulants for Management of Cervical Artery Dissection: Interactive Systematic Review and Meta-analysis
- Bilingual Status
- complete