Meta AnalysisID 5475
维生素B1（硫胺素）治疗感染性休克的疗效：一项随机对照试验的Meta分析
CRD42022330097
The aim of this meta-analysis of randomized controlled trials is to evaluate the efficacy of vitamin B1 for septic shock.
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Record Fields
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- Meta Analysis Id
- 5475
- Evidence Id
- 14033
- Core Evidence Id
- 14033
- Source Meta Analysis Id
- 5458
- Herb2 Meta Analysis Id
- HBMA005458
- Crd Id
- CRD42022330097
- Title
- The efficacy of vitamin B1 (thiamine) in the treatment of septic shock: a meta-analysis of randomized controlled trials
- Review Question
- The aim of this meta-analysis of randomized controlled trials is to evaluate the efficacy of vitamin B1 for septic shock.
- Study Type Included
- Prospective and randomized trials.
- Condition Being Studied
- Septic shock plays an important roles in the Intensive Care Unit. Although many efforts have been made to prevent and treat septic shock, the incidence and mortality are still high. Vitamin B1 is an important coenzyme of glucose metabolism. There have been many studies on exogenous supplementation of vitamin B1 for patients with septic shock, in order to enhance the oxygen supply, reduce the content of blood lactic acid, protect organ function, and improve the prognosis of patients. Until now, the conclusion is not unified. This paper reviews the mechanism and recent related research of vitamin B1 in septic shock.
- Participant
- Inclusion:1. Type of trials: randomized controlled clinical and parallel trials.2.Population: trials including adult population with septic shock which is defined by Sepsis 3.0. 3. Intervention: patients submitted to vitamin b1 for therapy. 4. Comparison: placebo or glucocorticoid. 5. Outcome: the primary outcome was shock-free days during the first 7 or 28 days. Exclusion:1. They were not published in English or Chinese. 2. They were not published as original articles. 3. They did not use adult patients. 4. They included no data on the primary outcome in patients with septic shock. 5. Full-text articles were not available.
- Animal
- Human Disease Modelled
- Intervention
- Vitamin B1 were used intravenously. The interventions of interest were specified with vitamin B1, irrespective of dose, duration, or co-intervention.
- Comparator Control
- Placebo.
- Main Outcome
- resolution of shock Measures of effect Resolution of shock was defined as the time from starting blinded study medications to discontinuation of all vasopressor support.
- Outcome Measure
- Additional Outcome
- 1.all-cause mortality 2.change in Sequential Organ Failure Assessment (SOFA) score. 3.lactate level Measures of effect 1.Studies with all-cause mortality, including ICU mortality, hospital mortality, 28-day mortality, 90-day mortality or mortality at any other time points. 2. Change in SOFA score was defined as the initial SOFA score minus the SOFA score of the day when study medications were discontinued.
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Hospital Mortality; Humans; Randomized Controlled Trials as Topic; Shock, Septic; Thiamine
- Contact
- Jingyuan Xu [email protected]
- Organisational Affiliation
- Zhongda Hospital, Southeast University
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-05-05
- Registration Date
- 2022-05-16
- Anticipated Start Date
- 2021-11-11
- Anticipated Completion Date
- 2022-08-01
- Title Cn
- 维生素B1（硫胺素）治疗感染性休克的疗效：一项随机对照试验的Meta分析
- Title En
- The efficacy of vitamin B1 (thiamine) in the treatment of septic shock: a meta-analysis of randomized controlled trials
- Bilingual Status
- complete