Meta AnalysisID 5464
直接口服抗凝药对比维生素K拮抗剂对左心室血栓的疗效与安全性：一项更新的系统评价与Meta分析
CRD42022324075
How does efficacy and safety of direct oral anticoagulants versus vitamin K antagonists for the treatment of left ventricular thrombus?
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 5464
- Evidence Id
- 14022
- Core Evidence Id
- 14022
- Source Meta Analysis Id
- 5447
- Herb2 Meta Analysis Id
- HBMA005447
- Crd Id
- CRD42022324075
- Title
- Efficacy and safety of direct oral anticoagulants versus vitamin K antagonists for left ventricular thrombus: an updated systematic review and meta-analysis
- Review Question
- How does efficacy and safety of direct oral anticoagulants versus vitamin K antagonists for the treatment of left ventricular thrombus?
- Study Type Included
- We will include randomised and observational studies to compare the outcomes associated with direct oral anticoagulants use and vitamin K antagonists use for the treatment of LV thrombi.
- Condition Being Studied
- Left ventricular thrombus. Stroke. Systemic embolization. Bleeding.
- Participant
- Inclusion: Adults with left ventricular thrombus. Exclusion: Adolescents (under 18 years of age).
- Animal
- Human Disease Modelled
- Intervention
- Although vitamin K antagonists are recommended as first‐line anticoagulants for patients with left ventricular thrombus, accumulating evidence suggests direct oral anticoagulants could be a safe alternative. Efficacy and safety of direct oral anticoagulants should be assessed to justify their usage in this population.
- Comparator Control
- Standard care: vitamin K antagonists-only. Comparator care: direct oral anticoagulants-only.
- Main Outcome
- The primary efficacy outcome was stroke or systemic embolism event rate, and the primary safety outcome was bleeding.
- Outcome Measure
- Additional Outcome
- The secondary efficacy outcome was LV trombi resolution rate. Measures of effect Odds ratios.
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Anticoagulants; Humans; Thrombosis; Vitamin K
- Contact
- Ruzina Evgeniya [email protected]
- Organisational Affiliation
- A.N. Bakoulev National medical research center for cardiovascular surgery of Ministry of Health of the Russian Federation, Moscow Russian Federation www.bakulev.ru
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English, Russian
- Country
- Russian Federation
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-04-08
- Registration Date
- 2022-05-09
- Anticipated Start Date
- 2022-04-08
- Anticipated Completion Date
- 2022-06-08
- Title Cn
- 直接口服抗凝药对比维生素K拮抗剂对左心室血栓的疗效与安全性：一项更新的系统评价与Meta分析
- Title En
- Efficacy and safety of direct oral anticoagulants versus vitamin K antagonists for left ventricular thrombus: an updated systematic review and meta-analysis
- Bilingual Status
- complete