Meta AnalysisID 535
中药三七制剂治疗急性心肌梗死的临床疗效与安全性：随机对照试验的系统评价
CRD42021242485
To investigate the clinical efficacy and safety of the Chinese herbal medicine Sanchi(Sanqi) preparation for the treatment of acute myocardial infarction.
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Record Fields
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- Meta Analysis Id
- 535
- Evidence Id
- 9093
- Core Evidence Id
- 9093
- Source Meta Analysis Id
- 511
- Herb2 Meta Analysis Id
- HBMA000511
- Crd Id
- CRD42021242485
- Title
- The clinical efficacy and safety of the Chinese herbal medicine Sanchi(Sanqi) preparation for the treatment of acute myocardial infarction: a systematic review of randomized controlled trials.
- Review Question
- To investigate the clinical efficacy and safety of the Chinese herbal medicine Sanchi(Sanqi) preparation for the treatment of acute myocardial infarction.
- Study Type Included
- We will include all the RCTs that investigated the effectiveness and safety of Sanchi(Sanqi) preparation.
- Condition Being Studied
- Sanchi(Sanqi) is a traditional Chinese herb with the medicinal function “promoting the circulation”, has been used for cardio-cerebrovascular diseases with a long history. In traditional Chinese medicine, Sanchi(Sanqi) preparation is the common drug for treating blood stasis syndrome, and blood stasis is the main pathological mechanism of ischemic heart disease. Activating Blood is the basic principle of treating Qi deficiency and blood stasis. Sanchi(Sanqi) contains panax notoginseng saponins, dencichin, gypenoside and other components. The contemporary use of Sanchi(Sanqi) mainly focuses on its Anti-inflammatory, antioxidant and hemostasis. In cardiovascular research Sanchi(Sanqi) preparation increases coronary flow, reduces myocardial oxygen consumption and lowers arterial pressure. There have been many reports of Sanchi(Sanqi) preparation in the treatment of AMI, but commonly the sample sizes of these studies are small and the level of evidences are not high. Therefore, this study intends to carry out a meta-analysis on the efficacy and safety of Sanchi(Sanqi) preparation in the treatment of patients with AMI, in order to provide better evidence for clinical practice.
- Participant
- Patients diagnosed as AMI regardless of their age, sex, ethnicity, education, or economic, status, and whether or not they are outpatients or inpatients. The diagnostic criteria of AMI should be confirmed according to one of the past or current definitions.
- Animal
- Human Disease Modelled
- Intervention
- A combination of Sanchi(Sanqi) preparation with conventional pharmacotherapy. The use of Sanchi(Sanqi) combined with other herbal medicines will be excluded.
- Comparator Control
- The same conventional pharmacotherapy must be used in the control group.
- Main Outcome
- The primary outcome measures will be AMI-related clinical evaluation, including left ventricular end-diastolic volume (LVEDV), left ventricular end-systolic volume (LVESV), left ventricular mass index (LVMI), left ventricular ejection fraction (LVEF), rate of recanalization, mortality, incidence of reperfusion arrhythmias, angina pectoris after infarction, re-infarction rate. Measures of effect The primary outcome measures will be AMI-related clinical evaluation, including left ventricular end-diastolic volume (LVEDV), left ventricular end-systolic volume (LVESV), left ventricular mass index (LVMI), left ventricular ejection fraction (LVEF), rate of recanalization, mortality, incidence of reperfusion arrhythmias, angina pectoris after infarction, re-infarction rate.
- Outcome Measure
- Additional Outcome
- Incidence of unfavorable reactions; rate of effective of TCM treatment. Measures of effect Incidence of unfavorable reactions; rate of effective of TCM treatment.
- Study Method
- Systematic review
- Keyword
- Drugs, Chinese Herbal; Humans; Myocardial Infarction; Randomized Controlled Trials as Topic; Treatment Outcome; sanqi
- Contact
- Hui Wang [email protected]
- Organisational Affiliation
- Beijing University of Chinese Medicine
- Funding Source
- National Nature Science Foundation of China Grant number(s) <span style=font-size: 14px>State the funder, grant or award number and the date of award</span> Grant No. 81774031
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- Chinese-Simplified, English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2021-03-13
- Registration Date
- 2021-04-12
- Anticipated Start Date
- 2020-06-02
- Anticipated Completion Date
- 2021-06-01
- Title Cn
- 中药三七制剂治疗急性心肌梗死的临床疗效与安全性：随机对照试验的系统评价
- Title En
- The clinical efficacy and safety of the Chinese herbal medicine Sanchi(Sanqi) preparation for the treatment of acute myocardial infarction: a systematic review of randomized controlled trials.
- Bilingual Status
- complete