Meta AnalysisID 534

三七制剂治疗急性卒中

CRD42015029749

To prove whether applying sanchi can help patients to recover better. To prove whether applying sanchi is safe. To compare the effectiveness of sanchi preparation with other Chinese traditional medicines. To compare the

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Meta Analysis Id: 534
Evidence Id: 9092
Core Evidence Id: 9092
Source Meta Analysis Id: 510
Herb2 Meta Analysis Id: HBMA000510
Crd Id: CRD42015029749
Title: Sanchi preparation for acute stroke
Review Question: To prove whether applying sanchi can help patients to recover better. To prove whether applying sanchi is safe. To compare the effectiveness of sanchi preparation with other Chinese traditional medicines. To compare the effectiveness of sanchi preparation and basic medicine with basic medicine only.
Study Type Included: We will include randomised controlled trials (RCTs) comparing sanchi agents with placebo or open control (no placebo) in patients with acute ischaemic stroke. We will telephone interview the study authors if the studies are alleged to be RCTs but have poor reporting of methodology and will exclude those that are not properly randomised.
Condition Being Studied: Stroke, also known as cerebrovascular accident (CVA), cerebrovascular insult (CVI), or brain attack, is when poor blood flow to the brain results in cell death. There are two main types of stroke: ischemic, due to lack of blood flow, and hemorrhagic, due to bleeding. They result in part of the brain not functioning properly. Signs and symptoms of a stroke may include an inability to move or feel on one side of the body, problems understanding or speaking, feeling like the world is spinning, or loss of vision to one side among others. Signs and symptoms often appear soon after the stroke has occurred. If symptoms last less than one or two hours it is known as a transient ischemic attack (TIA). Hemorrhagic strokes may also be associated with a severe headache. The symptoms of a stroke can be permanent. Long term complications may include pneumonia or loss of bladder control. The main risk factor for stroke is high blood pressure.Other risk factors include tobacco smoking, obesity, high blood cholesterol, diabetes mellitus, previous TIA, and atrial fibrillation among others. An ischemic stroke is typically caused by blockage of a blood vessel. A hemorrhagic stroke is caused by bleeding either directly into the brain or into the space surrounding the brain. Bleeding may occur due to a brain aneurysm. Diagnosis is typically with medical imaging such as a CT scan or MRI scan along with a physical exam. Other tests such as an electrocardiogram (ECG) and blood tests are done to determine risk factors and rule out other possible causes. Low blood sugar may cause similar symptoms. Prevention includes decreasing risk factors as well as possibly aspirin, statins, surgery to open up the arteries to the brain in those with problematic narrowing, and warfarin in those with atrial fibrillation. A stroke often requires emergency care. An ischemic stroke, if detected within three to four and half hours, may be treatable with a medication that can break down the clot. Aspirin should be used. Some hemorrhagic strokes benefit from surgery. Treatment to try recover lost function is called stroke rehabilitation and ideally takes place in a stroke unit; however, these are not available in much of the world. In 2010 approximately 17 million people had a stroke and 33 million people had previously had a stroke and were still alive. Between 1990 and 2010 the number of strokes which occurred each year decreased by approximately 10% in the developed world and increased by 10% in the developing world. In 2013, stroke was the second most frequent cause of death after coronary artery disease, accounting for 6.4 million deaths (12% of the total).About 3.3 million deaths resulted from ischemic stroke while 3.2 million deaths resulted from hemorrhagic stroke. About half of people who have had a stroke live less than one year.Overall, two thirds of strokes occurred in those over 65 years old.
Participant: Trials including patients of any age or sex with acute stroke (within 30 days of onset) will be eligible for inclusion. The clinical definition of ischaemic stroke will follow the criteria of the World Health Organization, and diagnosis will be via computerised tomography (CT) or magnetic resonance imaging (MRI).
Animal
Human Disease Modelled
Intervention: Sanchi agents versus placebo or no intervention, regardless of administration route, dosage, or length of treatment. Co-interventions will be allowed if offered equally to both arms of the trial. Compound sanchi agents that contain other herbal extracts or other active elements will be excluded because the other components may interfere with the evaluation of the efficacy of sanchi. Sanchi agents compared to other active treatment will also be excluded.
Comparator Control: We will include randomised controlled trials (RCTs) comparing sanchi agents with placebo or open control (no placebo) in patients with acute ischaemic stroke.
Main Outcome: Whether applying sanchi preparation is safe. Whether applying sanchi preparation has a beneficial effect on recovery in patients. Measures of effect After two weeks without symptoms, we will calculate the NIHSS score, the Barthel score, whether the treatment is unsafe and accident rates.
Outcome Measure
Additional Outcome: None.
Study Method
Keyword: Drugs, Chinese Herbal; Humans; Medicine, Chinese Traditional; Stroke; Treatment Effectiveness
Contact: Jia Qi [email protected]
Organisational Affiliation: Beijing University of Chinese Medicine http://www.bucm.edu.cn/
Funding Source: Beijing University of Chinese Medicine and my tutor will support this project. If this funding is not sufficient, all members and I will support this project by oursleves.
Other Selection Criteria
Final Publication
Same Topic Review
Published Protocol
Review Type
Language: Chinese-Simplified
Country: China
Review Stage: Review Ongoing
First Submission Date
Registration Date: 2015-11-27
Anticipated Start Date: 2015-12-01
Anticipated Completion Date: 2016-05-31
Title Cn: 三七制剂治疗急性卒中
Title En: Sanchi preparation for acute stroke
Bilingual Status: complete