Meta AnalysisID 5232
维生素C联合维生素B1对脓毒症患者的效果
CRD42021226771
The purpose of this study is to determine whether vitamin C combination with vitamin B1 can improve the prognosis of patients with sepsis.
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 5232
- Evidence Id
- 13790
- Core Evidence Id
- 13790
- Source Meta Analysis Id
- 5214
- Herb2 Meta Analysis Id
- HBMA005214
- Crd Id
- CRD42021226771
- Title
- The effect of vitamin C combination with vitamin B1 on patients with sepsis
- Review Question
- The purpose of this study is to determine whether vitamin C combination with vitamin B1 can improve the prognosis of patients with sepsis.
- Study Type Included
- Randomized controlled trials (RCTs) were included, irrespective of the publication date, setting, and risk of bias.
- Condition Being Studied
- Sepsis is a life-threatening organ dysfunction caused by dysregulated host response to infection, while septic shock is a subset of sepsis with circulatory and cellular/ metabolic dysfunction associated with a higher risk of mortality. Septic shock is a major healthcare problem that contributes to the most common causes of death in the intensive care unit.
- Participant
- Patients with sepsis who received vitamin C and vitamin B1 were enrolled in this review.
- Animal
- Human Disease Modelled
- Intervention
- The interventions of interest were specified with vitamin C and vitamin B1, irrespective of dose and duration.
- Comparator Control
- The patients with sepsis who received common therapies were included in the control group.
- Main Outcome
- The main outcome is all-cause mortality. Measures of effect Odds ratio (OR) with 95% confidence interval (CI) was used to calculate the difference for all-cause mortality.
- Outcome Measure
- Additional Outcome
- The duration of vasoactive agents was evaluated in this review. Measures of effect Standardized mean difference (SMD) with 95% CI was used to calculate the difference for the duration of vasoactive agents.
- Study Method
- Intervention, Meta-analysis, Systematic review
- Keyword
- Ascorbic Acid; Humans; Sepsis; Thiamine
- Contact
- Jun Lu [email protected]
- Organisational Affiliation
- Affiliated Hospital of Nanjing University of Chinese Medicine
- Funding Source
- National Natural Science Fund of China, A Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) and The Open Projects of the Discipline of Chinese Medicine of Nanjing University of Chinese Medicine Supported by the Subject of Academic priority discipline of Jiangsu Higher Education Institutions. Grant number(s) <span style=font-size: 14px>State the funder, grant or award number and the date of award</span> The grant numbers are 81704048, 82074379 and ZYX03KF080.
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2020-12-17
- Registration Date
- 2021-01-16
- Anticipated Start Date
- 2021-01-01
- Anticipated Completion Date
- 2021-01-30
- Title Cn
- 维生素C联合维生素B1对脓毒症患者的效果
- Title En
- The effect of vitamin C combination with vitamin B1 on patients with sepsis
- Bilingual Status
- complete