Meta AnalysisID 5190
异常维生素B6水平在帕金森病患者中潜在作用的系统评价
CRD42022212316
What is the potential role of abnormal vitamin B6 levels in patients with Parkinson's disease?
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Record Fields
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- Meta Analysis Id
- 5190
- Evidence Id
- 13748
- Core Evidence Id
- 13748
- Source Meta Analysis Id
- 5172
- Herb2 Meta Analysis Id
- HBMA005172
- Crd Id
- CRD42022212316
- Title
- A systematic review of the potential role of abnormal vitamin B6 levels in patients with Parkinson's disease
- Review Question
- What is the potential role of abnormal vitamin B6 levels in patients with Parkinson's disease?
- Study Type Included
- No restrictions on the types of study.
- Condition Being Studied
- Parkinson's disease
- Participant
- Inclusion criteria: Patients with Parkinson's disease. Exclusion criteria: Patients with known causes of abnormal vitamin B6 levels (malabsorption, malnutrition, alcoholism, cancer, medications, etc.). Patients with known causes of neuropathy (diabetes, hypothyroidism, etc.). Patients with known causes of epileptic seizures (stroke, brain lesions, etc.).
- Animal
- Human Disease Modelled
- Intervention
- Abnormal levels of vitamin B6, including deficient and abnormally high levels. Vitamin B6 levels are measured by fasting plasma levels of pyridoxal 5'-phosphate (vitamin B6). For most laboratories, the normal range is 20-125 nmol/L. A level of <20 nmol/L is considered deficient. A level of >125 nmol/L is considered abnormally high (at risk for toxicity).
- Comparator Control
- Normal vitamin B6 levels. Vitamin B6 levels are measured by fasting serum levels of pyridoxal 5'-phosphate (vitamin B6). For most laboratories, the normal range is 20-125 nmol/L. A level of <20 nmol/L is considered deficient. A level of >125 nmol/L is considered abnormally high (at risk for toxicity).
- Main Outcome
- - Estimated frequencies of normal and abnormal vitamin B6 levels- Presence of symptomatic neuropathy (with or without nerve conduction studies or electromyography) - Presence of epileptic seizures (with or without electroencephalography) Measures of effect Percentages. Odds ratios.
- Outcome Measure
- Additional Outcome
- - Presence of pre-symptomatic abnormalities consistent with neuropathy on nerve conduction studies or electromyography. - Presence of pre-symptomatic epileptiform abnormalities on electroencephalography. Measures of effect Odds ratios.
- Study Method
- Diagnostic, Epidemiologic, Individual patient data (IPD) meta-analysis, Intervention, Narrative synthesis, Prevention, Systematic review, Other
- Keyword
- Humans; Parkinson Disease; Vitamin B 6
- Contact
- Karlo Lizarraga [email protected]
- Organisational Affiliation
- University of Rochester
- Funding Source
- None Grant number(s) <span style=font-size: 14px>State the funder, grant or award number and the date of award</span>
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Canada, United States of America
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-05-10
- Registration Date
- 2022-05-20
- Anticipated Start Date
- 2021-05-20
- Anticipated Completion Date
- 2022-12-31
- Title Cn
- 异常维生素B6水平在帕金森病患者中潜在作用的系统评价
- Title En
- A systematic review of the potential role of abnormal vitamin B6 levels in patients with Parkinson's disease
- Bilingual Status
- complete