Meta AnalysisID 516
阿拉伯茶与神经行为功能：一项系统评价
CRD42020159580
Is there a difference in executive function performance in adults who chew khat compared to healthy controls?
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Record Fields
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- Meta Analysis Id
- 516
- Evidence Id
- 9074
- Core Evidence Id
- 9074
- Source Meta Analysis Id
- 489
- Herb2 Meta Analysis Id
- HBMA000489
- Crd Id
- CRD42020159580
- Title
- Khat and neurobehavioural functions: a systematic review
- Review Question
- Is there a difference in executive function performance in adults who chew khat compared to healthy controls?
- Study Type Included
- We will include experimental, quasi-experimental and cross-sectional studies used a healthy control group. In addition, studies that have measured neural activation using either fMRI or EEG whilst participants performed a cognitive task.
- Condition Being Studied
- Khat is a plant substance mainly consumed in East Africa and the Arabian Peninsula for its psychostimulant effect analog to that of amphetamine. There is a substantial body of literature that suggests prolonged khat use has a negative impact on physical and mental health. To understand the neuropsychological effects of khat use this review seeks to explore the literature on the executive ‘higher-order’ functioning in adults with a khat dependency.
- Participant
- Inclusion of: Studies that look at habitual khat users, long-term khat users (Chronic), adults, animal studies (rodents), and with no limit of consumption. Exclusion of: Past khat users, occasional users, under 18 years old.
- Animal
- Human Disease Modelled
- Intervention
- All original articles that introduce the following inclusion/exclusion criteria(s): Inclusion criteria: Adults who uses khat, Quasi-experiments, Lab-based experiments cross-sectional studies, Longitudinal studies, No limits of addiction Executive functions tasks /assessment Neuropsychological batteries Neuroimaging techniques (fMRI and EEG only) Exclusion criteria: Non-cognitive/behavioural task use Non-neuropsychological testing Non-neuropsychological tasks Other community/educational settings No khat free control group
- Comparator Control
- Khat-free control (adults who do not use khat); amphetamine; synthetic cathinone.
- Main Outcome
- The primary outcome of interest are studies that have examined the long-term effects of khat usage on executive function and/or reported Impaired cognitive/Neurobehavioral process. Studies will be allocated to neuroimaging technique domains: functional magnetic resonance imaging (fMRI) or electroencephalography (EEG). Studies that have examined executive function using standardised neuropsychological assessment tools/measures. Executive function may include measures of the following cognitive domains: attention, problem-solving/executive functions, reward- or impulse-related functions, social cognition, visuospatial abilities; the speed of processing, verbal fluency/language, verbal learning, verbal memory, visual learning, visual memory, and working memory, inhibitory control. Measures of effect Not applicable.
- Outcome Measure
- Additional Outcome
- For the neuroimaging studies the following information will be extracted: fMRI studies: design (block or event-related), coordinate space, contrasts performed, and device information. EEG studies: EEG reference, number of electrodes, components analysed and the device information. Measures of effect Not applicable.
- Study Method
- Narrative synthesis, Systematic review
- Keyword
- Catha; Choline O-Acetyltransferase; Humans
- Contact
- Ayan Ahmed [email protected]
- Organisational Affiliation
- University of Surrey www.surrey.ac.uk
- Funding Source
- Other Selection Criteria
- Final Publication
- Ahmed A, Ruiz M, Cohen Kadosh K, Patton R, Resurrección D. Khat and neurobehavioral functions: A systematic review. PLOS ONE. 2021;16(6):e0252900. https://journals.plos.org/plosone/article/metrics?id=10.1371/journal.pone.0252900
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- England, Spain
- Review Stage
- Review Completed published
- First Submission Date
- 2019-11-22
- Registration Date
- 2020-01-17
- Anticipated Start Date
- 2019-12-23
- Anticipated Completion Date
- 2020-02-01
- Title Cn
- 阿拉伯茶与神经行为功能：一项系统评价
- Title En
- Khat and neurobehavioural functions: a systematic review
- Bilingual Status
- complete