Meta AnalysisID 4872
维生素K2预防和治疗绝经后骨质疏松症的疗效和安全性：十九项随机对照试验的Meta分析
CRD42017070250
To determine whether vitamin K2 can prevent and treat osteoporosis in postmenopausal women.
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 4872
- Evidence Id
- 13430
- Core Evidence Id
- 13430
- Source Meta Analysis Id
- 4845
- Herb2 Meta Analysis Id
- HBMA004845
- Crd Id
- CRD42017070250
- Title
- The efficacy and safety of vitamin K2 in the prevention and treatment of postmenopausal osteoporosis: a meta-analysis of nineteen randomized controlled trials
- Review Question
- To determine whether vitamin K2 can prevent and treat osteoporosis in postmenopausal women.
- Study Type Included
- Randomized controlled trials.
- Condition Being Studied
- Postmenopausal women with osteoporosis.
- Participant
- Inclusion: postmenopausal healthy women with or without osteoporosis (as diagnosed using any recognised diagnostic criteria). Exclusion: patients with secondary osteoporosis (e.g., due to major gastrointestinal surgery, steroid therapy, rheumatoid arthritis, premenopausal bilateral oophorectomy, renal dysfunction, and thyroid dysfunction), patients taking medications which could affect bone turnover (such as bisphosphonates, estrogen, calcitonin, SERM, or warfarin) and male subjects.
- Animal
- Human Disease Modelled
- Intervention
- Vitamin K2.
- Comparator Control
- Placebo or other positive drugs.
- Main Outcome
- Bone mineral density (BMD), and the incidence of fractures (vertebral and non-vertebral fractures).
- Outcome Measure
- Additional Outcome
- Undercarboxylated osteocalcin (uc-OC), osteocalcin (OC), and adverse events.
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Bone Density; Female; Humans; Menopause; Osteoporosis, Postmenopausal; Patient Safety; Safety; Treatment Outcome; Vitamin K 2
- Contact
- Li Xiong [email protected]
- Organisational Affiliation
- Shenyang Pharmaceutical University http://www.syphu.edu.cn/
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- Registration Date
- 2017-06-25
- Anticipated Start Date
- 2017-03-05
- Anticipated Completion Date
- 2017-07-31
- Title Cn
- 维生素K2预防和治疗绝经后骨质疏松症的疗效和安全性：十九项随机对照试验的Meta分析
- Title En
- The efficacy and safety of vitamin K2 in the prevention and treatment of postmenopausal osteoporosis: a meta-analysis of nineteen randomized controlled trials
- Bilingual Status
- complete