Meta AnalysisID 4767
血管加压素治疗心脏骤停的有效性：系统评价的再评估系统评价与再Meta分析
CRD42022334077
What is the effectiveness of vasopressin alone or vasopressin combined with other drugs (e.g. epinephrine, steroid) compared with placebo, epinephrine alone, or epinephrine combined with non-vasopressin drugs (e.g. stero
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Record Fields
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- Meta Analysis Id
- 4767
- Evidence Id
- 13325
- Core Evidence Id
- 13325
- Source Meta Analysis Id
- 4733
- Herb2 Meta Analysis Id
- HBMA004733
- Crd Id
- CRD42022334077
- Title
- Effectiveness of vasopressin for cardiac arrest: A systematic review of systematic reviews with re-meta-analysis
- Review Question
- What is the effectiveness of vasopressin alone or vasopressin combined with other drugs (e.g. epinephrine, steroid) compared with placebo, epinephrine alone, or epinephrine combined with non-vasopressin drugs (e.g. steroid) on improving patient outcomes (e.g. return of spontaneous circulation, survival to hospital admission, survival to hospital discharge, favorable neurological outcome) for adult patients with in-hospital or out-of-hospital cardiac arrest?
- Study Type Included
- Systematic reviews and meta-analyses will be eligible for inclusion in this review.
- Condition Being Studied
- In-hospital or out-of-hospital cardiac arrest will be the condition being studied in this systematic review.
- Participant
- Adult patients (≥18 years) suffering from in-hospital or out-of-hospital cardiac arrest and treated with vasopressin will be included in this systematic review. Conversely, animal samples and adult patients suffering from traumatic cardiac arrest will be excluded from this systematic review.
- Animal
- Human Disease Modelled
- Intervention
- The intervention will be the administration of vasopressin alone or vasopressin combined with other drugs (e.g. epinephrine, steroid).
- Comparator Control
- The comparator will be the administration of placebo, epinephrine alone, or epinephrine combined with non-vasopressin drugs (e.g. steroid).
- Main Outcome
- The primary outcome will be return of spontaneous circulation (i.e. resumption of sustained cardiac activity with significant respiratory effort). Measures of effect Odds ratios with 95% confidence intervals will be the effect measure for the primary outcome.
- Outcome Measure
- Additional Outcome
- The secondary outcomes will be survival to hospital admission (i.e. maintenance of spontaneous circulation on admission to the hospital), survival to hospital discharge (i.e. survival of ≥30 days after discharge from the hospital), and favorable neurological outcome (i.e. Glasgow-Pittsburgh Cerebral Performance Category of 1 or 2). Measures of effect Odds ratios with 95% confidence intervals will be the effect measure for the secondary outcomes.
- Study Method
- Intervention, Meta-analysis, Narrative synthesis, Systematic review
- Keyword
- Epinephrine; Heart Arrest; Humans; Systematic Reviews as Topic; Vasoconstrictor Agents; Vasopressins
- Contact
- Jonathan Ka-ming Ho [email protected]
- Organisational Affiliation
- Funding Source
- NA Grant number(s) <span style=font-size: 14px>State the funder, grant or award number and the date of award</span> NA
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Hong Kong
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-05-20
- Registration Date
- 2022-05-30
- Anticipated Start Date
- 2022-07-01
- Anticipated Completion Date
- 2022-12-31
- Title Cn
- 血管加压素治疗心脏骤停的有效性：系统评价的再评估系统评价与再Meta分析
- Title En
- Effectiveness of vasopressin for cardiac arrest: A systematic review of systematic reviews with re-meta-analysis
- Bilingual Status
- complete