Meta AnalysisID 4764
心肺复苏期间使用血管加压素的疗效：随机试验的Meta分析
CRD42022314216
What is the efficacy of vasopressin during CPR?
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Record Fields
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- Meta Analysis Id
- 4764
- Evidence Id
- 13322
- Core Evidence Id
- 13322
- Source Meta Analysis Id
- 4731
- Herb2 Meta Analysis Id
- HBMA004731
- Crd Id
- CRD42022314216
- Title
- Efficacy of Vasopressin During Cardiopulmonary Resuscitation : A Meta-Analysis of Randomized Trials
- Review Question
- What is the efficacy of vasopressin during CPR?
- Study Type Included
- Randomized clinical trials
- Condition Being Studied
- Cardiac arrest is the sudden inability of the heart to maintain sufficient perfusion to vital organs and results in more than 500, 000 deaths across the United States every year. Apart from chest compressions, arrhythmia control and airway management, current advanced cardiac life support guidelines by the American Heart Association recommend the use of 1 mg intravenous epinephrine every 3 to 5 minutes during cardiopulmonary resuscitation (CPR) and remains the standard of care globally. Vasopressin, also known as antidiuretic hormone, is a vasoactive peptide originating from the pituitary gland and its main function is to maintain serum osmolality, blood pressure and body sodium content. Vasopressin helps maintain blood pressure through different receptors compared with epinephrine. Furthermore, studies have found vasopressin levels to be significantly higher in patients who achieve return of spontaneous circulation (ROSC) Hence, it has been postulated that vasopressin might be a viable option as a vasoactive agent during CPR. Multiple randomized controlled trials (RCTs) have evaluated the use of vasopressin with or without steroids during CPR and yielded mixed results. Hence, we conducted a comprehensive meta-analysis of RCTs to investigate the efficacy of vasopressin compared with standard of care among patients with cardiac arrest.
- Participant
- Population include patients with cardiac arrest undergoing CPR. RCTs that compared the outcomes with vasopressin versus control during CPR will be included. We will include studies evaluating CPR for in-hospital or out of hospital cardiac arrest. Studies which did not report the clinical outcomes of CPR (including ROSC) and non-randomized studies will be excluded.
- Animal
- Human Disease Modelled
- Intervention
- Vasopressin during CPR among cardiac arrest patients.
- Comparator Control
- No vasopressin during CPR among cardiac arrest patients.
- Main Outcome
- The primary outcome of the study is the achievement of return of spontaneous circulation after CPR among the vasopressin versus control groups, as defined per each study.
- Outcome Measure
- Additional Outcome
- The secondary outcomes include in-hospital mortality, ventricular arrhythmias and achievement of favorable neurological outcome
- Study Method
- Intervention, Systematic review
- Keyword
- Cardiopulmonary Resuscitation; Heart Arrest; Humans; Randomized Controlled Trials as Topic; Vasopressins
- Contact
- Ayman Elbadawi [email protected]
- Organisational Affiliation
- Baylor College of Medicine
- Funding Source
- None.
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- United States of America
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-03-03
- Registration Date
- 2022-04-03
- Anticipated Start Date
- 2022-03-04
- Anticipated Completion Date
- 2022-04-01
- Title Cn
- 心肺复苏期间使用血管加压素的疗效：随机试验的Meta分析
- Title En
- Efficacy of Vasopressin During Cardiopulmonary Resuscitation : A Meta-Analysis of Randomized Trials
- Bilingual Status
- complete