Meta AnalysisID 4732
肠道菌群将膳食前体转化为尿石素A的性能：一项系统评价
CRD42022357020
1. How does gut bacteria produce urolithin A within the human body? 2. How can safe organic urolithin A be obtained outside the human body? 3. Does the ingestion of preformed urolithin A have the same effects as the body
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 4732
- Evidence Id
- 13290
- Core Evidence Id
- 13290
- Source Meta Analysis Id
- 4702
- Herb2 Meta Analysis Id
- HBMA004702
- Crd Id
- CRD42022357020
- Title
- A systematic review of the performance of gut bacteria in the conversion of Urolithin A from its dietary precursors
- Review Question
- 1. How does gut bacteria produce urolithin A within the human body? 2. How can safe organic urolithin A be obtained outside the human body? 3. Does the ingestion of preformed urolithin A have the same effects as the body-made urolithin A? 4. Why do only 40% of people have the ability to convert urolithin A from the precursors? 5. Is there any means of making a non-urolithin A producer become a urolithin A producer? 6. Why is the conversion of urolithin A is done by specific bacteria?
- Study Type Included
- 1. Laboratory experimental studies 2. Clinical trials 3. Observational studies
- Condition Being Studied
- This study focuses on the mechanisms of action on how urolithin A is developed inside the human body and external the human body, how the urolithin A made from both ways functions within the body, what are the target sites of urolithin A, what enzymes and hormones facilitate its functionality and what hinders its production and functionality. At the end of the day, this information obtained will help the developers of the product (performed urolithin A) to come up with a stable and quality product that can meet human requirements and target sites.
- Participant
- 1. Bacteria 2. Human subjects 3. Laboratory animals
- Animal
- Human Disease Modelled
- Intervention
- All studies with urolithin A formulation involving the specific type of bacteria, the site of conversation, optimal conditions for obtaining the bacteria capable of producing urolithin A, and optimal methods for urolithin A production.
- Comparator Control
- Comparator or control is not relevant in this case
- Main Outcome
- 1. Ways to obtain urolithin A outside the human body using the specific bacteria and food sources rich in ellagitannins. 2. How to ensure the developed urolithin A functions the same as in made urolithin A and performs the targeted health benefits
- Outcome Measure
- Additional Outcome
- Studies showing the current urolithin A supplements, the dosage used, and the effects associated with the supplements. Effect of urolithin A in aging
- Study Method
- Meta-analysis, Methodology, Systematic review
- Keyword
- 3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one; Bacteria; Coumarins; Humans
- Contact
- Caroline Massanga [email protected]
- Organisational Affiliation
- Nelson Mandela African Institution of Science and Technology
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Tanzania
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-08-30
- Registration Date
- 2022-09-10
- Anticipated Start Date
- 2022-10-01
- Anticipated Completion Date
- 2023-01-01
- Title Cn
- 肠道菌群将膳食前体转化为尿石素A的性能：一项系统评价
- Title En
- A systematic review of the performance of gut bacteria in the conversion of Urolithin A from its dietary precursors
- Bilingual Status
- complete