Meta AnalysisID 4723
尿酸与系统性红斑狼疮肾脏结局的相关性：一项Meta分析与系统评价
CRD42021284557
Our study aimed to examine the association between serum uric acid level and lupus nephritis development and progression in systemic lupus erythematosus patients.
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 4723
- Evidence Id
- 13281
- Core Evidence Id
- 13281
- Source Meta Analysis Id
- 4693
- Herb2 Meta Analysis Id
- HBMA004693
- Crd Id
- CRD42021284557
- Title
- Association between Uric Acid and Systemic Lupus Erythematosus Kidney Outcome: A Meta-analysis and Systemic Review
- Review Question
- Our study aimed to examine the association between serum uric acid level and lupus nephritis development and progression in systemic lupus erythematosus patients.
- Study Type Included
- Studies were considered for inclusion using the following criteria: (a) was an original article published in English; (b) clearly defined serum uric acid level or hyperuricemia and any diagnosis of lupus nephritis or kidney dysfunction in systemic lupus erythematosus patients; (c) investigated either continuous or categorial lupus kidney involvement; (d)used diagnosis of hyperuricemia status or continuous serum uric acid level; (f) provided quantitative measures of the association between hyperuricemia status or serum uric acid level and lupus nephritis, and their 95% confidence intervals (CIs); and (g) used cross-sectional, case-control or cohort epidemiological study design. Exclusion criteria were as follows: (a) review studies, case reports, animal studies, or letters to the editor; (b) the publication did not clearly define clinical outcomes; (c) the articles did not provide valid data; (d) the publication provided duplicated data; and (e) the mean age of the study population was under 18 years.
- Condition Being Studied
- Lupus nephritis and hyperuricemia.
- Participant
- Inclusion: Adults with systemic lupus erythematosus (as diagnosed using any recognized diagnostic criteria). Exclusion: Adolescents (under 18 years of age) and elderly people (over 70).
- Animal
- Human Disease Modelled
- Intervention
- Hyperuricemia was defined as a serum uric acid level over about 6.2 mg/dl (but would varied according to each research articles).
- Comparator Control
- Systemic lupus erythematosus patients with normal serum uric acid level.
- Main Outcome
- The effect of hyperuricemia on the development and progression of lupus nephritis in systemic lupus erythematosus (SLE) patients. Measures of effect Pooled odds ratio and relative risks.
- Outcome Measure
- Additional Outcome
- Not applicable Measures of effect Not applicable
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Humans; Kidney; Lupus Erythematosus, Systemic; Uric Acid
- Contact
- Min Yang [email protected]
- Organisational Affiliation
- Nanfang Hospital, Southern Medical University http://www.smu.edu.cn/
- Funding Source
- National Natural Science Foundation of China (Grant No. 81771747) Grant number(s) <span style=font-size: 14px>State the funder, grant or award number and the date of award</span> National Natural Science Foundation of China (Grant No. 81771747) 2017-07
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2021-10-13
- Registration Date
- 2021-11-13
- Anticipated Start Date
- 2021-06-18
- Anticipated Completion Date
- 2022-05-04
- Title Cn
- 尿酸与系统性红斑狼疮肾脏结局的相关性：一项Meta分析与系统评价
- Title En
- Association between Uric Acid and Systemic Lupus Erythematosus Kidney Outcome: A Meta-analysis and Systemic Review
- Bilingual Status
- complete