Meta AnalysisID 4722
肌少症与尿酸的相关性：一项系统评价与Meta分析
CRD42021272753
To investigate the association between serum uric acid concentrations and the prevalence of sarcopenia (i.e., muscle strength, muscle mass and/or physical function) through a meta-analysis.
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 4722
- Evidence Id
- 13280
- Core Evidence Id
- 13280
- Source Meta Analysis Id
- 4692
- Herb2 Meta Analysis Id
- HBMA004692
- Crd Id
- CRD42021272753
- Title
- Association between sarcopenia and uric acid: a systematic review and meta-analysis
- Review Question
- To investigate the association between serum uric acid concentrations and the prevalence of sarcopenia (i.e., muscle strength, muscle mass and/or physical function) through a meta-analysis.
- Study Type Included
- We included all case-control studies, cohort studies or cross-sectional studies focusing on the association between sarcopenia and uric acid.
- Condition Being Studied
- Sarcopenia is a progressive and generalized skeletal muscle disorder that is associated with increased likelihood of falls, disability and mortality. Sarcopenia is defined by low muscle strength and low muscle quantity or quality. It occurs commonly as an age-related process in older people and has significant impact on their life course. Sarcopenia has become the focus of intense research aiming to translate current knowledge about its pathophysiology into improved diagnosis and treatment, and the relationship between several disorders, including hyperuricemia. Uric acid is the end-product of purine metabolism in the human body. Humans are exposed to >50 times greater serum uric acid concentrations than other mammals because of the lack of urate oxidase, an enzyme that is responsible for uric acid being converted into allantoin, which makes humans susceptible to hyperuricemia. Apart from being a diagnostic indicator of gout, blood uric acid has been associated with metabolic syndrome, chronic kidney disease, and stroke. The association between serum uric acid concentrations and the prevalence of sarcopenia was controversial; however, no meta-analysis has been conducted to examine the aforementioned association.
- Participant
- We included studies that examined the relationship between sarcopenia and blood uric acid. Inclusion criteria: (1) human study, (2) case-control study or cohort study or cross-sectional study, (3) studies focusing on the association between sarcopenia and blood uric acid, (4) those that reported correlation coefficients or odds ratios (ORs) along with 95 % confidence intervals or the standardized regression coefficient (β), means and standard deviations for sarcopenia and blood uric acid, and (5) studies published in any language. Exclusion criteria: (1) animal study, (2) in vitro or laboratory study, (3) review or case report, (4) studies not providing sufficient data to calculate, and (5) abstract/title only publications.
- Animal
- Human Disease Modelled
- Intervention
- Our main form of exposure were: 1) serum uric acid concentrations; 2) the prevalence of hyperuricemia.
- Comparator Control
- Those with different level of serum uric acid concentrations or individuals without hyperuricemia were set as control in this study.
- Main Outcome
- 1) The prevalence of sarcopenia; 2) muscle strength; 3) muscle mass; 4) physical performance (e.g., gait speed, SPPB score)
- Outcome Measure
- Additional Outcome
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Humans; Odds Ratio; Risk Factors; Sarcopenia; Uric Acid
- Contact
- Yilun Wang [email protected]
- Organisational Affiliation
- Central South University
- Funding Source
- This work was supported by the Project Program of National Clinical Research Center for Geriatric Disorders (Xiangya Hospital, 2020LNJJ03).
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2021-08-10
- Registration Date
- 2021-09-10
- Anticipated Start Date
- 2021-06-01
- Anticipated Completion Date
- 2021-09-10
- Title Cn
- 肌少症与尿酸的相关性：一项系统评价与Meta分析
- Title En
- Association between sarcopenia and uric acid: a systematic review and meta-analysis
- Bilingual Status
- complete