Meta AnalysisID 4721
降尿酸治疗对CKD患者的影响：网状Meta分析
CRD42021253825
P: CKD patients I: uric acid lowering therapy C: other uric acid lowering therapy (including placebo) O: renal function, AEs
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 4721
- Evidence Id
- 13279
- Core Evidence Id
- 13279
- Source Meta Analysis Id
- 4691
- Herb2 Meta Analysis Id
- HBMA004691
- Crd Id
- CRD42021253825
- Title
- Effects of uric acid lowering therapy in CKD patients: network meta-analysis.
- Review Question
- P: CKD patients I: uric acid lowering therapy C: other uric acid lowering therapy (including placebo) O: renal function, AEs
- Study Type Included
- randomized controlled trials
- Condition Being Studied
- Hyperuricemia is one of the most common complications of CKD. The major symptoms caused by hyperuricemia is gout. In recent years, however, hyperuricemia has been shown to be involved in the development and progression of CKD. It has also been shown to be associated with a variety of diseases closely related to CKD, including hypertension, type 2 diabetes, obesity, heart failure, and cardiovascular disease. In general, the proportion of patients with hyperuricemia increases as renal function declines. Therefore, hyperuricemia and CKD form a negative spiral, adversely affecting each other. Conversely, for hyperuricemia patients with CKD, treatment of hyperuricemia may help to preserve their renal function. In fact, several studies have shown that therapeutic intervention with uric acid-lowering drugs in patients with hyperuricemia was beneficial in preserving renal function. On the other hand, contrary to expectations, some studies have shown that uric-acid-lowering therapy (ULT) is not beneficial in preserving renal function.Whether or not ULT is beneficial in preserving renal function in CKD patients with hyperuricemia is a very important topic.
- Participant
- Studies are eligible for inclusion if they (i) were RCTs; (ii) included adults (age ≥18) with CKD (defined as estimated glomerular filtration rate (eGFR) < 60 ml/min/1.73 m2 and/or proteinuria and/or albuminuria); (iii) compared uric acid lowering medicine with placebo; (iv) followed participants for at least 3 months post-randomization; and (v) reported any of the following outcomes: changes in eGFR, serum creatinine, albuminuria or proteinuria from baseline to the end of study.
- Animal
- Human Disease Modelled
- Intervention
- uric acid lowering therapy
- Comparator Control
- other uric acid lowering therapy (including placebo)
- Main Outcome
- change in kidney function (eGFR) from baseline to last measurement or the end of follow-up.
- Outcome Measure
- Additional Outcome
- changes in serum uric acid, albuminuria, proteinuria and the incidence of adverse events.
- Study Method
- Network meta-analysis, Systematic review
- Keyword
- Glomerular Filtration Rate; Humans; Network Meta-Analysis; Renal Insufficiency, Chronic; Uric Acid
- Contact
- Shunichiro Tsukamoto [email protected]
- Organisational Affiliation
- Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine
- Funding Source
- Other Selection Criteria
- Final Publication
- Tsukamoto S, et al. Prevention of kidney function decline using uric acid-lowering therapy in chronic kidney disease patients: a systematic review and network meta-analysis. Clin Rheumatol. 2021 Oct 12. doi: 10.1007/s10067-021-05956-5. Epub ahead of print. PMID: 34642880.
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Japan
- Review Stage
- Review Completed published
- First Submission Date
- 2021-05-08
- Registration Date
- 2021-06-07
- Anticipated Start Date
- 2021-02-01
- Anticipated Completion Date
- 2021-06-12
- Title Cn
- 降尿酸治疗对CKD患者的影响：网状Meta分析
- Title En
- Effects of uric acid lowering therapy in CKD patients: network meta-analysis.
- Bilingual Status
- complete