Meta AnalysisID 4720
降尿酸治疗对高尿酸血症患者心血管和肾脏的影响：一项系统评价与贝叶斯网状Meta分析
CRD42021226163
This study aims to compare the relative efficacy and risk of different uric acid-lowing therapy on cardiovascular in adult patients with hyperuricemia by means of systematic review and network meta-analysis within a Baye
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Ingredient: 1Meta-analysis: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 4720
- Evidence Id
- 13278
- Core Evidence Id
- 13278
- Source Meta Analysis Id
- 4690
- Herb2 Meta Analysis Id
- HBMA004690
- Crd Id
- CRD42021226163
- Title
- The cardiovascular and kidney effects of uric acid lowering therapy in patients with hyperuricemia: a systematic review and bayesian network meta-analysis
- Review Question
- This study aims to compare the relative efficacy and risk of different uric acid-lowing therapy on cardiovascular in adult patients with hyperuricemia by means of systematic review and network meta-analysis within a Bayesian framework.
- Study Type Included
- RCT and cohort study
- Condition Being Studied
- Management of chronic kidney dieases and cardiovascular disease.
- Participant
- Adult participants were diagnosed as hyperuricemia. Data from subgroups of participants with CKD within studies with broader inclusion criteria were also included.
- Animal
- Human Disease Modelled
- Intervention
- Uric acid-lowing agents which were administrated at any dose for more than 12 weeks.
- Comparator Control
- Standard care, placebo or no .
- Main Outcome
- If the data allow: 1. the occurrence of major cardiovascular events : cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, heart failure requiring hospitalization, and unstable angina requiring urgent coronary revascularization. Measures of effect relative risks
- Outcome Measure
- Additional Outcome
- If the data allow: 1. Change in serum uric acid level (mg/dl); 2. Remission of ischemic cardiomyopathy; 3. Kidney failure events are defined as: More than 25% or 50% decrease in the estimated GFR (eGFR)* Doubling of serum creatinine End stage renal disease (ESRD); 4..Rate of change in eGFR: the difference from baseline in eGFR divided by the number of years between creatinine measurements (ml/min/1.73m2 per year); 5. Major adverse events, including rash, arthralgia, gastrointestinal symptoms and other drug-related adverse events. Measures of effect relative risks
- Study Method
- Systematic review
- Keyword
- Bayes Theorem; Humans; Hyperuricemia; Kidney; Network Meta-Analysis; Uric Acid
- Contact
- Yaqing Zhang [email protected]
- Organisational Affiliation
- Shanxi Medical University Second Hospital
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2021-01-04
- Registration Date
- 2021-02-04
- Anticipated Start Date
- 2020-12-03
- Anticipated Completion Date
- 2021-11-01
- Title Cn
- 降尿酸治疗对高尿酸血症患者心血管和肾脏的影响：一项系统评价与贝叶斯网状Meta分析
- Title En
- The cardiovascular and kidney effects of uric acid lowering therapy in patients with hyperuricemia: a systematic review and bayesian network meta-analysis
- Bilingual Status
- complete