Meta AnalysisID 4719
降尿酸治疗对慢性肾脏病进展的影响：随机对照试验的Meta分析
CRD42020213157
The aim of this meta-analysis of randomized controlled trials is to evaluate the efficacy of uric acid-lowering therapy on the progression of chronic Kidney disease.
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 4719
- Evidence Id
- 13277
- Core Evidence Id
- 13277
- Source Meta Analysis Id
- 4689
- Herb2 Meta Analysis Id
- HBMA004689
- Crd Id
- CRD42020213157
- Title
- Effects of uric acid-lowering therapy on the Progression of Chronic Kidney Disease：A meta-analysis of randomized controlled trials
- Review Question
- The aim of this meta-analysis of randomized controlled trials is to evaluate the efficacy of uric acid-lowering therapy on the progression of chronic Kidney disease.
- Study Type Included
- Randomized controlled trials.
- Condition Being Studied
- Chronic kidney disease (CKD) has become a global public health issue. The prevalence of CKD in the United States in 2012 (not including end-stage renal disease) was estimated at 13.6% by the US Renal Data System and the prevalence of CKD was as high as 10.8% in a survey of a nationally representative sample of Chinese adults. Management of the progression of CKD aims to address a multiplicity of factors that are involved. The burden of CKD was not only restricted to progress to end-stage renal disease (ESRD) requiring renal replacement therapy, but also associated with high mortality, cardiovascular events, hospitalization and healthcare costs. Therefore, early detection and intervention of associated risk factors are essential for delaying, even preventing CKD. Published data implicate elevated serum uric acid concentration with the evolution of CKD, or vice versa, and the relationship could be circular, with each worsening the other.
- Participant
- Included studies should fulfill the following inclusion criteria: (1) studies enrolled adult patients with CKD. Chronic kidney disease was defined according to the KDOQI guideline, or as defined by study authors, (2) only experimental group was given uric acid lowering therapy, (3) studies were randomized controlled trials, (4) studies reported the following renal outcomes: changes in GFR , incidence of worsening of renal function or ESRD. Exclusion criteria: (1) studies reporting on patients with ESRD or acute renal impairment or renal carcinoma or patients requiring dialysis or kidney transplant; (2) children; (3) reviews, commentary articles,and editorials.
- Animal
- Human Disease Modelled
- Intervention
- Effects of uric acid-lowering therapy (including allopurinol, benzbromarone, probenecid, febuxostat, rasburicase, and pegloticase) was the main intervention
- Comparator Control
- Placebo control.
- Main Outcome
- Changes in eGFR Measures of effect Changes in eGFR from baseline to the end of follow-up.
- Outcome Measure
- Additional Outcome
- renal outcome Measures of effect ESRD, the percentage of decrease in the eGFR
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Glomerular Filtration Rate; Humans; Hyperuricemia; Randomized Controlled Trials as Topic; Renal Insufficiency, Chronic; Uric Acid
- Contact
- Shaojie Zhang [email protected]
- Organisational Affiliation
- Anhui Medical University
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2020-10-09
- Registration Date
- 2020-11-09
- Anticipated Start Date
- 2020-09-10
- Anticipated Completion Date
- 2021-01-01
- Title Cn
- 降尿酸治疗对慢性肾脏病进展的影响：随机对照试验的Meta分析
- Title En
- Effects of uric acid-lowering therapy on the Progression of Chronic Kidney Disease：A meta-analysis of randomized controlled trials
- Bilingual Status
- complete