Meta AnalysisID 4717
血/口腔尿酸与牙周炎的相关性：一项系统评价与Meta分析
CRD42020172535
Are there different levels of uric acid in blood, saliva or gingival cervical fluid (GCF) in periodontitis patients compared with periodontally healthy controls?
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 4717
- Evidence Id
- 13275
- Core Evidence Id
- 13275
- Source Meta Analysis Id
- 4685
- Herb2 Meta Analysis Id
- HBMA004685
- Crd Id
- CRD42020172535
- Title
- Association between blood/oral uric acid and periodontitis: A systematic review and meta‐analysis
- Review Question
- Are there different levels of uric acid in blood, saliva or gingival cervical fluid (GCF) in periodontitis patients compared with periodontally healthy controls?
- Study Type Included
- Included studies: Observational studies including prospective/retrospective cohort, cross-sectional and case-control study; and interventional studies (randomized and non-randomized controlled trials) with a recording of baseline/pre-treatment uric acid levels. Excluded studies: Duplicated studies, unavailabe full-text, untranslatable articles by the reviewers, case reports, case series, animal study, in-vitro study, narrative/systematic review, conference abstract, editorial, letter, comment, etc.
- Condition Being Studied
- Periodontitis.
- Participant
- Inclusion: (1) Periodontitis patients and periodontally healthy controls should have uric acid levels in blood, saliva or GCF measured ; (2) participants with systemic health; (3) participants with gout/hyperuricemia should have no systemic complications such as renal dysfunction (including abnormal glomerular filtration rate); (4) participants in interventional studies should have baseline/pre-treatment uric acid levels recorded. Exclusion: (1) studies without periodontitis patients or periodontally healthy controls; (2) female subjects during pregnancy; (3) subjects with potential comorbidites shared by hyperuricemia and periodontitis, such as cardiovascular diseases, diabetes, osteoporosis, chronic kidney disease, metaboic syndrome and obesity; (4) subjects with other potential conditions associated with altered purine/uric acid metabolism such as inflammatory bowel diseases, hyperparathyroidism and vitamin D deficiency; (5) subjects with significant systemic diseases or conditions such as cancers, liver cirrhosis, etc; (6) and subjects receiving antibiotics or anti‐inflammatory or urate-lowering drugs or having periodontal treatment in the past 3 months.
- Animal
- Human Disease Modelled
- Intervention
- Exposure: periodontitis. The effect of periodontitis on uric acid levels will be assessed.
- Comparator Control
- Control: periodontally healthy individuals. Uric acid levels in in blood, saliva or GCF in periodontitis patients vs. periodontally healthy controls will be compared.
- Main Outcome
- Uric acid levels in blood, saliva and GCF. Measures of effect Uric acid levels or concentrations can be detected with spectral (ultraviolet absorption, fluorescence), electrochemical (voltammetry, electrochemiluminescence, surface plasmon resonance), chromatography (liquid and gas phase), capillary electrophoresis and isotope dilution mass spectrometry based on enzymatic or non-enzymatic strategies. Uric acid levels can be reported as a continuous variable and statistically presented as mean±standard deviation, median (IQR or min-max). Uric acid levels can also be reported as a grouping variable, which can be categorized using different cut-off point or divided by median/tertile/quartile/quintile. Serum uric acids levels can be divided into hyperuricemia and normouricemia.
- Outcome Measure
- Additional Outcome
- None Measures of effect None
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Humans; Periodontitis; Risk Factors; Uric Acid
- Contact
- Ting Yu [email protected]
- Organisational Affiliation
- Department of Periodontology, Key Laboratory of Oral Medicine, Guangzhou Institute of Oral Disease, Stomatology Hospital of Guangzhou Medical University, Guangzhou, China. Department of Prosthodontics, Guanghua School of Stomatology, Sun Yat-sen University and Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, China.
- Funding Source
- National Natural Science Foundation of China, Beijing, China Grant number(s) <span style=font-size: 14px>State the funder, grant or award number and the date of award</span> Grant 81700985
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2020-03-06
- Registration Date
- 2020-04-28
- Anticipated Start Date
- 2020-02-27
- Anticipated Completion Date
- 2020-08-01
- Title Cn
- 血/口腔尿酸与牙周炎的相关性：一项系统评价与Meta分析
- Title En
- Association between blood/oral uric acid and periodontitis: A systematic review and meta‐analysis
- Bilingual Status
- complete