Meta AnalysisID 4716
比较不同降尿酸疗法及其对慢性肾脏病进展的影响
CRD42020167467
Does the use of specific uric acid-lowering therapy result in better outcomes (defined by change in creatinine, change in eGFR, development of end-stage renal failure, or the need for renal replacement therapy) relative
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 4716
- Evidence Id
- 13274
- Core Evidence Id
- 13274
- Source Meta Analysis Id
- 4684
- Herb2 Meta Analysis Id
- HBMA004684
- Crd Id
- CRD42020167467
- Title
- Comparing uric acid-lowering therapies and their effects on the progression of chronic kidney disease
- Review Question
- Does the use of specific uric acid-lowering therapy result in better outcomes (defined by change in creatinine, change in eGFR, development of end-stage renal failure, or the need for renal replacement therapy) relative to other uric acid-lowering therapies?
- Study Type Included
- Randomised controlled trials.
- Condition Being Studied
- Chronic kidney disease. Hyperuricaemia.
- Participant
- Adults on different uric acid-lowering therapies.
- Animal
- Human Disease Modelled
- Intervention
- Use of uric acid-lowering therapies, including: Allopurinol; Febuxostat; Sulfinpyrazone; Benzbromarone.
- Comparator Control
- Other uric acid-lowering therapies (different drug-drug comparisons).
- Main Outcome
- Mean changes in serum creatinine over the duration of the study. Measures of effect We are currently awaiting advice from a statistician to determine how duration of the study would impact on renal function, and if there is any method we can use to correct for this. We may use change in renal function per year as an outcome.
- Outcome Measure
- Additional Outcome
- Mean change in eGFR. Development of end stage renal failure. Requirement for renal replacement therapy. Measures of effect We are currently awaiting advice from a statistician to determine how duration of the study would impact on renal function, and if there is any method we can use to correct for this. We may use change in renal function per year as an outcome.
- Study Method
- Intervention, Meta-analysis, Systematic review
- Keyword
- Disease Management; Disease Progression; Drug Therapy; Humans; Hyperuricemia; Kidney Failure, Chronic; Renal Insufficiency, Chronic; Treatment Outcome; Uric Acid
- Contact
- Greg Guthrie [email protected]
- Organisational Affiliation
- University of Dundee
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Scotland
- Review Stage
- Review Ongoing
- First Submission Date
- 2020-01-31
- Registration Date
- 2020-02-03
- Anticipated Start Date
- 2020-01-31
- Anticipated Completion Date
- 2021-01-04
- Title Cn
- 比较不同降尿酸疗法及其对慢性肾脏病进展的影响
- Title En
- Comparing uric acid-lowering therapies and their effects on the progression of chronic kidney disease
- Bilingual Status
- complete