Meta AnalysisID 4699
尿素呼气试验诊断幽门螺杆菌感染的最佳截断值：系统评价和Meta分析的方案
CRD42021272076
Which cut-off values were optimal for urea breath test in diagnosing helicobacter pylori infection?
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 4699
- Evidence Id
- 13257
- Core Evidence Id
- 13257
- Source Meta Analysis Id
- 4667
- Herb2 Meta Analysis Id
- HBMA004667
- Crd Id
- CRD42021272076
- Title
- Optimal cut-off values for diagnosing helicobacter pylori infection with urea breath test: A protocol of systematic review and meta-analysis.
- Review Question
- Which cut-off values were optimal for urea breath test in diagnosing helicobacter pylori infection?
- Study Type Included
- Any applicable study, no special restrictions. But review, letter, meeting abstract, notes, comments, editorials, protocol, guidelines, case reports and case series will be excluded.
- Condition Being Studied
- Helicobacter pylori infection remains one of the most prevalent infections worldwide, especially in low-resource countries. Helicobacter pylori infection has been implicated in a number of malignancies and non-malignant conditions including peptic ulcers, non-ulcer dyspepsia, recurrent peptic ulcer bleeding, unexplained iron deficiency anaemia, and colorectal adenomas. Currently, various diagnostic methods are available for detecting these infections, urea breath test is may a highly sensitive and specific and allows to diagnose the presence or absence of infection of H. pylori, through the oral administration of a solution containing urea labelled with the non-radioactive and radioactive natural carbon. However, the urea breath test has many clinical diagnostic cut-off values, and there are certain differences between the cut-off values, which may affect the diagnosis of Helicobacter infection.
- Participant
- Population with doing urea breath test for detection of H. pylori infection. However we considered only endoscopic biopsy followed by histology (using haemotoxylin and eosin (H & E) stain, special histological stains such as Giemsa stain and Warthin-Starry stain, or immunohistochemical stain) as the reference standard/ gold standard for diagnosis of H pylori infection.
- Animal
- Human Disease Modelled
- Intervention
- The intervention is mainly 13C/14C urea breath test. 13C/14C-urea breath test(13C/14C-UBT) is known to be a good diagnostic method for detecting H. pylori infection since it is non-invasive, simple and accurate. The UBT is based on the principle, that isotopically labelled urea ingested by an H. pylori--infected patient is rapidly hydrolysed by the microbial urease. The released 13/14CO2 is absorbed across the mucous layer to the gastric mucosa and hence, excreted via the systemic circulation in the breath which is collected and measured.
- Comparator Control
- Not applicable
- Main Outcome
- The diagnostic accuracy of urea breath test in different cut-off values for helicobacter pylori infection. Measures of effect Sensitivity, specificity, false positive rate, and false negative rate, positive likelihood ratio and negative likelihood ratio, Diagnostic odds ratio(DOR).
- Outcome Measure
- Additional Outcome
- Study Method
- Diagnostic, Meta-analysis, Systematic review
- Keyword
- Breath Tests; Helicobacter Infections; Helicobacter pylori; Humans; Meta-Analysis as Topic; Systematic Reviews as Topic; Urea
- Contact
- Anya Shi [email protected]
- Organisational Affiliation
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2021-09-06
- Registration Date
- 2021-10-07
- Anticipated Start Date
- 2021-08-05
- Anticipated Completion Date
- 2022-08-05
- Title Cn
- 尿素呼气试验诊断幽门螺杆菌感染的最佳截断值：系统评价和Meta分析的方案
- Title En
- Optimal cut-off values for diagnosing helicobacter pylori infection with urea breath test: A protocol of systematic review and meta-analysis.
- Bilingual Status
- complete