Meta AnalysisID 4696
口服尿素补充治疗住院成人低钠血症：一项系统评价和Meta分析
CRD42019127987
1. Primary: Among hospitalized adults with hyponatremia (P), how does oral urea supplementation (I) affect serum sodium levels (O)? 2. Secondary: Among hospitalized adults with hyponatremia (P), is oral urea supplementat
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 4696
- Evidence Id
- 13254
- Core Evidence Id
- 13254
- Source Meta Analysis Id
- 4663
- Herb2 Meta Analysis Id
- HBMA004663
- Crd Id
- CRD42019127987
- Title
- Oral urea supplementation in the treatment of hyponatremia among hospitalized adults: a systematic review and meta-analysis
- Review Question
- 1. Primary: Among hospitalized adults with hyponatremia (P), how does oral urea supplementation (I) affect serum sodium levels (O)? 2. Secondary: Among hospitalized adults with hyponatremia (P), is oral urea supplementation (I) safe and well-tolerated (O)?
- Study Type Included
- Randomized clinical trials, cohort studies will be included; reviews, meta-analyses, case reports will be excluded.
- Condition Being Studied
- Acute, non-hypovolemic hyponatremia among hospitalized adults
- Participant
- Hospitalized adults (>17 years old) with acute hyponatremia (any severity, symptomatic & asymptomatic).
- Animal
- Human Disease Modelled
- Intervention
- Oral urea supplementation: Powdered supplemental urea taken by mouth or by enteral feeding tube; it is used for the correction of hyponatremia by promoting electrolyte-free water excretion. Recommended dosing for oral urea supplementation is 0.25-0.50 g/kg per day, and duration varies based upon patient response (may be provided for days, weeks, or months). For the purposes of this study, oral urea supplementation will be considered the predictor variable; any dosing regimen will be included, and studies utilizing intravenous urea will be excluded.
- Comparator Control
- None.
- Main Outcome
- Serum sodium levels: Also referred to as plasma sodium, serum sodium, or sodium concentrations in clinical practice and in the literature. Serum sodium levels may be identified using indirect (plasma) or direct (whole blood) measurements, and practices vary between studies and institutions. It is recommended that when monitoring serum sodium levels in the treatment of hyponatremia, either method is acceptable, but utilizing one method (rather than assessing both plasma and whole blood measurements) provides the best estimate of correction trajectories. Normal serum sodium levels range from 135 mEq/L to 145 mEq/L. For the purposes of this study, baseline serum sodium level will be considered that reported at the time of oral urea initiation, and change in serum sodium from baseline (in mEq/L) will be the primary outcome of interest. Measures of effect None
- Outcome Measure
- Additional Outcome
- Safety: For the purposes of this study, safety will be reported using the measures of mortality (both hospital and ICU mortality), LOS, and incidence of ODS. Tolerability: For the purposes of this study, tolerability will be assessed using measures of gastrointestinal side effects (nausea, dysgeusia, gastroesophageal reflux, diarrhea, or vomiting) reported within the reviewed studies. Measures of effect None
- Study Method
- Narrative synthesis, Systematic review
- Keyword
- Adult; Humans; Hyponatremia; Urea
- Contact
- Emily Schwartz [email protected]
- Organisational Affiliation
- Rutgers University / Compass Group
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- United States of America
- Review Stage
- Review Completed not published
- First Submission Date
- 2019-03-08
- Registration Date
- 2019-04-09
- Anticipated Start Date
- 2018-11-12
- Anticipated Completion Date
- 2019-11-30
- Title Cn
- 口服尿素补充治疗住院成人低钠血症：一项系统评价和Meta分析
- Title En
- Oral urea supplementation in the treatment of hyponatremia among hospitalized adults: a systematic review and meta-analysis
- Bilingual Status
- complete