Meta AnalysisID 4682
酒精中毒中色氨酸分解代谢物的变化：系统评价与Meta分析
CRD42022357640
Growing evidence suggests an abnormal catabolism of tryptophan in alcoholic people. However, these studies were conducted in different time periods and there is a great variation in study designs. Conflicting results hav
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 4682
- Evidence Id
- 13240
- Core Evidence Id
- 13240
- Source Meta Analysis Id
- 4649
- Herb2 Meta Analysis Id
- HBMA004649
- Crd Id
- CRD42022357640
- Title
- Tryptophan catabolite changes in alcoholism: a systematic review and meta-analysis
- Review Question
- Growing evidence suggests an abnormal catabolism of tryptophan in alcoholic people. However, these studies were conducted in different time periods and there is a great variation in study designs. Conflicting results have also been found between studies. This systematic review and meta-analysis aimed at assessing the possible differences in tryptophan catabolites between alcoholic individuals and controls.
- Study Type Included
- Eligible studies were those: (1) observational studies including subjects with alcoholism, alcohol use disorder, alcohol dependence, alcohol withdrawal syndrome or hazardous drinking, diagnosed according to the Diagnostic and Statistical Manual of Mental Disorders (DSM), the International Classification of Diseases (ICD) criteria, Alcohol Use Disorders Identification Test or reviewed by specialist; (2) with non-alcoholic controls; (3) detecting at least one of tryptophan catabolites, including tryptophan, serotonin, kynurenine, kynurenic acid, quinolinic acid, 3-hydroxykynurenine, 5-hydroxyindoleacetic acid and ratios of these metabolites; (4) measuring concentrations of these compounds in human plasma, serum, cerebrospinal fluid or urine; (5) reported detailed data in the abstract or full text of papers. No restriction was made on the publication year or on the language of the papers. Studies that reported repeated data, or those full text or abstract was not available, or did not include detailed data, were excluded.
- Condition Being Studied
- Alcohol is the most extensive addictive substance in the world. The harmful use of alcohol causes increasing concern on the personal and public health, which results in more than 3.3 million deaths every year. Alcohol use disorder is highly comorbid with mental and physical diseases. The pathophysiology of alcohol use disorder remains to be fully elucidated but accumulating evidence have shown abnormal tryptophan catabolism in alcoholics.
- Participant
- Patients diagnosed with alcoholism, alcohol use disorder, alcohol dependence, alcohol withdrawal syndrome or hazardous drinking were used. The diagnosis criteria should be the Diagnostic and Statistical Manual of Mental Disorders, the International Classification of Diseases criteria, Alcohol Use Disorders Identification Test or carefully reviewed by an specialist.
- Animal
- Human Disease Modelled
- Intervention
- Baseline concentrations or ratios of tryptophan metabolites in blood, CSF and urine in alcoholics and controls were extracted. For study presenting patient groups with comorbidity such as depression and hepatic disease, only data of patients without accompanying disease was used.
- Comparator Control
- non-alcoholic control group
- Main Outcome
- Seperate meta-analyses are conducted to measure concentrations of tryptophan metabolites in blood, cerebrospinal fluid or urine of alcoholics compared to non-alcoholic controls. The names of metabolites have been provided in item 22. Measures of effect Pooled outcomes of mean differences and 95% confidence interval in these metabolites were estimated in separate meta-analyses. For metabolite in urine, standard mean difference estimated by Hedges' g was adopted because of the various units between studies.
- Outcome Measure
- Additional Outcome
- No
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Alcoholism; Humans; Tryptophan
- Contact
- Zhanzhang Wang [email protected]
- Organisational Affiliation
- Guangzhou Medical University Affilated Brain Hospital
- Funding Source
- This work was supported by the Natural Science Foundation of Guangdong Province (grant number 2021A1515011325), Science and Technology Plan Project of Guangzhou (grant number 202102080030, 202201010736), Scientific Research Project of Traditional Chinese Medicine Bureau of Guangdong Province (grant number 20222177), Science and Technology Plan Project of Guangdong Province (2019B0303160), and Guangzhou Municipal Key Discipline in Medicine (2021-2023). Grant number(s) <span style=font-size: 14px>State the funder, grant or award number and the date of award</span> 6
- Other Selection Criteria
- Final Publication
- Same Topic Review
- No existing review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-09-03
- Registration Date
- 2022-09-13
- Anticipated Start Date
- 2022-08-01
- Anticipated Completion Date
- 2022-10-04
- Title Cn
- 酒精中毒中色氨酸分解代谢物的变化：系统评价与Meta分析
- Title En
- Tryptophan catabolite changes in alcoholism: a systematic review and meta-analysis
- Bilingual Status
- complete